Effect of glutamate receptor antagonists on excitatory postsynaptic potentials in striatum

Ildikó Világi, Pál Kocsis, István Tarnawa, Ilona Banczerowski-Pelyhe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Glutamate, as the main transmitter of corticostriatal pathway, has a crucial role in the regulation of the activity of striatal cells as well as in pathogenesis of some diseases characterized by striatal malfunction caused by overexcitation of neurons. In the present study, the role of ionotropic excitatory amino acid receptors was investigated in the striatal synaptic transmission. Using conventional intracellular electrophysiological methods in brain slices, we have investigated the effects of the N-methyl-D- aspartate (NMDA) antagonist (±) 2-amino-5-phosphono-valerate (APV) and the α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) antagonist (±) 1- (4-aminophenyl)-3-methyl-carbamoyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 53655) on the excitatory postsynaptic potentials (EPSPs) evoked by electrical stimulation of corpus callosum. The AMPA antagonist significantly decreased electrically evoked responses and a weak inhibition was also observed after APV application. The results were compared to similar data obtained in a cortical slice study.

Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalBrain Research Bulletin
Volume46
Issue number6
DOIs
Publication statusPublished - Aug 1 1998

Keywords

  • Brain slice study
  • EPSPs
  • Excitatory amino acid antagonists
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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