Effect of glimepiride and glibenclamide, inhibitors of ATP-dependent K+-channel, on ischaemia-reperfusion induced arrhythmias in rats

Ö Bozdogan, I. Leprán, J. Papp

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Glibenclamide or glimepiride pretreatment (5 mg/kg ip. 30 min prior to coronary ligation) significantly improved the survival rate during reperfusion after 6 min myocardial ischaemia in rats (82% or 67% vs. 17% in controls). Smaller dose of glibenclamide (0.01 mg/kg) did not influence the survival rate (31%), while glimepiride still offered a significant protection (61%). These results suggest that different KATP inhibitors may increase the chance to survive life-threatening arrhythmias during myocardial ischaemia-reperfusion.

Original languageEnglish
Pages (from-to)265-266
Number of pages2
JournalActa Physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - 1996

Fingerprint

glimepiride
Glyburide
Reperfusion
Myocardial Ischemia
Cardiac Arrhythmias
Ischemia
Adenosine Triphosphate
Myocardial Reperfusion
Ligation

Keywords

  • Arrhythmias
  • Glibenclamide, glimepiride
  • Ischemia/reperfusion
  • Rat
  • Survival rate

ASJC Scopus subject areas

  • Physiology

Cite this

@article{148b72242db84aba855321fab237f7e2,
title = "Effect of glimepiride and glibenclamide, inhibitors of ATP-dependent K+-channel, on ischaemia-reperfusion induced arrhythmias in rats",
abstract = "Glibenclamide or glimepiride pretreatment (5 mg/kg ip. 30 min prior to coronary ligation) significantly improved the survival rate during reperfusion after 6 min myocardial ischaemia in rats (82{\%} or 67{\%} vs. 17{\%} in controls). Smaller dose of glibenclamide (0.01 mg/kg) did not influence the survival rate (31{\%}), while glimepiride still offered a significant protection (61{\%}). These results suggest that different KATP inhibitors may increase the chance to survive life-threatening arrhythmias during myocardial ischaemia-reperfusion.",
keywords = "Arrhythmias, Glibenclamide, glimepiride, Ischemia/reperfusion, Rat, Survival rate",
author = "{\"O} Bozdogan and I. Lepr{\'a}n and J. Papp",
year = "1996",
language = "English",
volume = "84",
pages = "265--266",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "3",

}

TY - JOUR

T1 - Effect of glimepiride and glibenclamide, inhibitors of ATP-dependent K+-channel, on ischaemia-reperfusion induced arrhythmias in rats

AU - Bozdogan, Ö

AU - Leprán, I.

AU - Papp, J.

PY - 1996

Y1 - 1996

N2 - Glibenclamide or glimepiride pretreatment (5 mg/kg ip. 30 min prior to coronary ligation) significantly improved the survival rate during reperfusion after 6 min myocardial ischaemia in rats (82% or 67% vs. 17% in controls). Smaller dose of glibenclamide (0.01 mg/kg) did not influence the survival rate (31%), while glimepiride still offered a significant protection (61%). These results suggest that different KATP inhibitors may increase the chance to survive life-threatening arrhythmias during myocardial ischaemia-reperfusion.

AB - Glibenclamide or glimepiride pretreatment (5 mg/kg ip. 30 min prior to coronary ligation) significantly improved the survival rate during reperfusion after 6 min myocardial ischaemia in rats (82% or 67% vs. 17% in controls). Smaller dose of glibenclamide (0.01 mg/kg) did not influence the survival rate (31%), while glimepiride still offered a significant protection (61%). These results suggest that different KATP inhibitors may increase the chance to survive life-threatening arrhythmias during myocardial ischaemia-reperfusion.

KW - Arrhythmias

KW - Glibenclamide, glimepiride

KW - Ischemia/reperfusion

KW - Rat

KW - Survival rate

UR - http://www.scopus.com/inward/record.url?scp=0030325616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030325616&partnerID=8YFLogxK

M3 - Article

VL - 84

SP - 265

EP - 266

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 3

ER -