Effect of GLG-V-13, a class III antiarrhythmic agent, on potassium currents in rabbit ventricular myocytes

L. Virág, Tamás Fazekas, N. Jost, A. Varró, K. Darrell Berlin, Benjamin J. Scherlag, Ralph Lazzara, J. Papp

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of a new Class III antiarrhythmic drug, GLG-V-13, on the 4- aminopyridine sensitive transient outward current, on the inward rectifier potassium current, on the ATP sensitive potassium current and on the rapid and slow components of the delayed rectifier potassium current were studied in single rabbit ventricular myocytes using the whole-cell voltage-clamp technique. GLG-V-13 blocked the rapid component of the delayed rectifier potassium current in a dose-dependent manner, with an estimated EC50 value of 0.36 μM. At high concentration, the slow component of the delayed rectifier potassium current was also depressed by the drug (40% effect at 10 μM concentration). The transient outward current, the inward rectifier potassium current and the ATP sensitive potassium current were not influenced by GLG-V-13, even at 10 μM concentration. Thus, GLG-V-13 blocks predominantly the rapid component of the delayed rectifier potassium current which may play a significant role in the prolongation of repolarization by the drug in ventricular tissue. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalLife Sciences
Volume66
Issue number17
Publication statusPublished - Mar 17 2000

Fingerprint

GLG-V 13
Muscle Cells
Potassium
Rabbits
Adenosine Triphosphate
4-Aminopyridine
Anti-Arrhythmia Agents
Clamping devices
Patch-Clamp Techniques
Pharmaceutical Preparations

Keywords

  • Cardiac myocytes
  • Class III antiarrhythmic drug
  • GLG-V- 13
  • Potassium currents

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of GLG-V-13, a class III antiarrhythmic agent, on potassium currents in rabbit ventricular myocytes. / Virág, L.; Fazekas, Tamás; Jost, N.; Varró, A.; Berlin, K. Darrell; Scherlag, Benjamin J.; Lazzara, Ralph; Papp, J.

In: Life Sciences, Vol. 66, No. 17, 17.03.2000, p. 253-258.

Research output: Contribution to journalArticle

Virág, L. ; Fazekas, Tamás ; Jost, N. ; Varró, A. ; Berlin, K. Darrell ; Scherlag, Benjamin J. ; Lazzara, Ralph ; Papp, J. / Effect of GLG-V-13, a class III antiarrhythmic agent, on potassium currents in rabbit ventricular myocytes. In: Life Sciences. 2000 ; Vol. 66, No. 17. pp. 253-258.
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