Effect of general anesthetics on amyloid precursor protein and mRNA levels in the rat brain

Miklós Palotás, András Palotás, Annamária Bjelik, Magdolna Pákáski, Marietta Hugyecz, Zoltán Janka, János Kálmán

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The incidence of Alzheimer's disease is elevated after exposure to surgical interventions. Since amyloid precursor protein (APP) and its neurotoxic derivatives play key roles in the development of Alzheimer dementia, the role of general anesthesia is controversial in the development of cognitive decline. As such, the effect of anesthetics on APP protein and mRNA levels was assessed utilizing semiquantitative Western-immunoblot and reverse transcription polymerase chain reaction (RT-PCR) in brains of rats following intraperitoneal treatment with propofol and thiopental. The anesthetics did not change cortical APP protein and mRNA concentration considerably. These results indicate that both propofol and thiopental are considered to be relatively safe with respect to APP metabolism.

Original languageEnglish
Pages (from-to)1021-1026
Number of pages6
JournalNeurochemical research
Volume30
Issue number8
DOIs
Publication statusPublished - Aug 1 2005

Keywords

  • Alzheimer's disease
  • Amyloid precursor protein
  • Cognitive dysfunction
  • General anesthetic
  • General surgery
  • Propofol
  • Thiopental

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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