Effect of fulvic and humic acids on performance, immune response and thyroid function in rats

A. V. Vucskits, I. Hullár, A. Bersényi, E. Andrásofszky, M. Kulcsár, J. Szabó

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Effect of humic acid (HA) and fulvic acid (FA) on production parameters, immune response and thyroid function of rats were investigated in two experiments. First experiment: control or 0.1%, 0.2%, 0.4%, 0.8% HA- or FA-supplemented diets. Second experiment: control and 0.4% HA- or FA-supplemented diets. The feeding period lasted 26 days in both trials. No significant changes were observed in production parameters. Ovalbumine antibody titre of rats on HA- or FA-supplemented diets showed dose-dependent (at 0.4% supplementation) and significant (p <0.05) increase (350 and 418% respectively) over the control (100%). Dose-related increase of plasma TSH (r = 0.99), and decrease of the T4/T3 ratio (r = -0.97) was observed in FA-supplemented rats. Second experiment: both FA and HA stimulated the immune response by the 14th day (mean values: control: 685.79; FA: 1131.37; HA: 1055.6099) and 26th day (control: 544.31; FA: 1969.83; HA: 1600.00). No significant differences were noted with lymphocyte stimulation test. Diameter of the 'B'-dependent lymphoid tissues in the ileum and spleen were significantly (p <0.05) larger in both the FA- and HA-treated animals. Humic acid and FA supplementation resulted in strong humoral immune stimulation. Our data also indicate that FA content is responsible for the mild hypothyroid effect of humic substances.

Original languageEnglish
Pages (from-to)721-728
Number of pages8
JournalJournal of Animal Physiology and Animal Nutrition
Volume94
Issue number6
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Humic Substances
thyroid function
fulvic acids
humic acids
Thyroid Gland
immune response
rats
Diet
fulvic acid
diet
humic substances
Lymphoid Tissue
lymphocyte proliferation
Lymphocyte Activation
dosage
Ileum
ileum
spleen
Spleen

Keywords

  • Fulvic acid
  • Humic acid immune response
  • Humic substance
  • Rat
  • Thyroid function

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Animals

Cite this

Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. / Vucskits, A. V.; Hullár, I.; Bersényi, A.; Andrásofszky, E.; Kulcsár, M.; Szabó, J.

In: Journal of Animal Physiology and Animal Nutrition, Vol. 94, No. 6, 12.2010, p. 721-728.

Research output: Contribution to journalArticle

Vucskits, A. V. ; Hullár, I. ; Bersényi, A. ; Andrásofszky, E. ; Kulcsár, M. ; Szabó, J. / Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. In: Journal of Animal Physiology and Animal Nutrition. 2010 ; Vol. 94, No. 6. pp. 721-728.
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