Effect of formaldehyde and resveratrol on the viability of Vero, HepG2 and MCF-7 cells

Z. L. Marcsek, Zs Kocsis, B. Szende, A. Tompa

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A non-transformed (Vero) and two tumor cell lines (HepG2 and MCF-7) were treated with 10 nM to 100 μM formaldehyde. Lower doses (10 nM to 10 μM) enhanced the viability of the cultured cells, measured by MTT assay. Higher doses (75-100 μM) decreased viability of the cells by 50% or more. The 100 μM concentration of HCHO has been chosen for combination treatment of the three cell lines with a series of concentrations (0.2-100 μM) of resveratrol, a phytoestrogen occurring in various fruits. Resveratrol decreased the cytotoxicity of formaldehyde depending on cell line and point of time, especially in case of MCF-7 cells at 24 and 72 h, Vero cells at 24 h and HepG2 cells at 48 h after treatment. Possible modes of interactions are discussed, considering the role of resveratrol in formaldehyde metabolism and also the estrogen receptor positivity of MCF-7 cells.

Original languageEnglish
Pages (from-to)1214-1219
Number of pages6
JournalCell biology international
Issue number10
Publication statusPublished - Oct 1 2007



  • Cell culture
  • Formaldehyde
  • HepG2
  • MCF-7
  • MTT assay
  • Resveratrol
  • Vero

ASJC Scopus subject areas

  • Cell Biology

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