Effect of fluconazole on the growth and adhesion of Candida albicans in the presence of antineoplastic agents

Katalin Fekete-Forgács, Bernadett Kis, G. Nagy, Béla Lenkey

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of fluconazole and the antineoplastic agents etoposide and methotrexate on the growth and adhesion of Candida albicans were studied. All the tested chemicals inhibited the growth and the adhesion of the yeast to buccal epithelial cells, while fluconazole and etoposide inhibited the adhesion to acrylate surface as well. Our experiments also demonstrated that etoposide and methotrexate interfered with the inhibitory effect of fluconazole on both the growth and cell adhesion. While etoposide strengthened the inhibitory effect of fluconazole, in the presence of methotrexate fluconazole showed lower inhibition on both the growth and adhesion.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalJournal of Basic Microbiology
Volume39
Issue number5-6
DOIs
Publication statusPublished - 1999

Fingerprint

Fluconazole
Candida albicans
Antineoplastic Agents
Etoposide
Methotrexate
Growth
Cheek
Cell Adhesion
Yeasts
Epithelial Cells

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Genetics

Cite this

Effect of fluconazole on the growth and adhesion of Candida albicans in the presence of antineoplastic agents. / Fekete-Forgács, Katalin; Kis, Bernadett; Nagy, G.; Lenkey, Béla.

In: Journal of Basic Microbiology, Vol. 39, No. 5-6, 1999, p. 305-310.

Research output: Contribution to journalArticle

Fekete-Forgács, Katalin ; Kis, Bernadett ; Nagy, G. ; Lenkey, Béla. / Effect of fluconazole on the growth and adhesion of Candida albicans in the presence of antineoplastic agents. In: Journal of Basic Microbiology. 1999 ; Vol. 39, No. 5-6. pp. 305-310.
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