Effect of fetal digoxin exposure (imprinting) on the sexual behavior of adult rats

Cs Karabélyos, G. Csaba

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Digoxin exposure of rat fetuses at the 15th, 17th and 19th day of pregnancy by treating the mother (with 9 μg digoxin altogether) caused alterations in the sexual behavior of adult rats (3-month-old males and six-month-old ovariectomized and hormone-treated females).The number of active males was significantly higher in the treated group and ejaculation as well as multiple ejaculation occurred only here. Females also were more receptable after fetal digoxin treatment. It is known from the literature that long-term digoxin treatment in adult age influences (reduces) the male sexual activity in humans. In the rat, the opposite effect was observed after fetal treatment.The experiments call attention to the prolonged effect of fetal digoxin exposure caused by the treatment of the mother. Copyright (C) 1998 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)367-369
Number of pages3
JournalGeneral Pharmacology
Volume31
Issue number3
DOIs
Publication statusPublished - Sep 1998

Fingerprint

Digoxin
Sexual Behavior
Ejaculation
Fetus
Imprinting (Psychology)
Hormones
Pregnancy

Keywords

  • Behavior
  • Cardioactive glycosides
  • Fetal treatment
  • Imprinting
  • Sexuality

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of fetal digoxin exposure (imprinting) on the sexual behavior of adult rats. / Karabélyos, Cs; Csaba, G.

In: General Pharmacology, Vol. 31, No. 3, 09.1998, p. 367-369.

Research output: Contribution to journalArticle

@article{171c31771ab549b9930fc9a7eff90186,
title = "Effect of fetal digoxin exposure (imprinting) on the sexual behavior of adult rats",
abstract = "Digoxin exposure of rat fetuses at the 15th, 17th and 19th day of pregnancy by treating the mother (with 9 μg digoxin altogether) caused alterations in the sexual behavior of adult rats (3-month-old males and six-month-old ovariectomized and hormone-treated females).The number of active males was significantly higher in the treated group and ejaculation as well as multiple ejaculation occurred only here. Females also were more receptable after fetal digoxin treatment. It is known from the literature that long-term digoxin treatment in adult age influences (reduces) the male sexual activity in humans. In the rat, the opposite effect was observed after fetal treatment.The experiments call attention to the prolonged effect of fetal digoxin exposure caused by the treatment of the mother. Copyright (C) 1998 Elsevier Science Inc.",
keywords = "Behavior, Cardioactive glycosides, Fetal treatment, Imprinting, Sexuality",
author = "Cs Karab{\'e}lyos and G. Csaba",
year = "1998",
month = "9",
doi = "10.1016/S0306-3623(98)00037-8",
language = "English",
volume = "31",
pages = "367--369",
journal = "Vascular Pharmacology",
issn = "1537-1891",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Effect of fetal digoxin exposure (imprinting) on the sexual behavior of adult rats

AU - Karabélyos, Cs

AU - Csaba, G.

PY - 1998/9

Y1 - 1998/9

N2 - Digoxin exposure of rat fetuses at the 15th, 17th and 19th day of pregnancy by treating the mother (with 9 μg digoxin altogether) caused alterations in the sexual behavior of adult rats (3-month-old males and six-month-old ovariectomized and hormone-treated females).The number of active males was significantly higher in the treated group and ejaculation as well as multiple ejaculation occurred only here. Females also were more receptable after fetal digoxin treatment. It is known from the literature that long-term digoxin treatment in adult age influences (reduces) the male sexual activity in humans. In the rat, the opposite effect was observed after fetal treatment.The experiments call attention to the prolonged effect of fetal digoxin exposure caused by the treatment of the mother. Copyright (C) 1998 Elsevier Science Inc.

AB - Digoxin exposure of rat fetuses at the 15th, 17th and 19th day of pregnancy by treating the mother (with 9 μg digoxin altogether) caused alterations in the sexual behavior of adult rats (3-month-old males and six-month-old ovariectomized and hormone-treated females).The number of active males was significantly higher in the treated group and ejaculation as well as multiple ejaculation occurred only here. Females also were more receptable after fetal digoxin treatment. It is known from the literature that long-term digoxin treatment in adult age influences (reduces) the male sexual activity in humans. In the rat, the opposite effect was observed after fetal treatment.The experiments call attention to the prolonged effect of fetal digoxin exposure caused by the treatment of the mother. Copyright (C) 1998 Elsevier Science Inc.

KW - Behavior

KW - Cardioactive glycosides

KW - Fetal treatment

KW - Imprinting

KW - Sexuality

UR - http://www.scopus.com/inward/record.url?scp=0032169689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032169689&partnerID=8YFLogxK

U2 - 10.1016/S0306-3623(98)00037-8

DO - 10.1016/S0306-3623(98)00037-8

M3 - Article

C2 - 9703203

AN - SCOPUS:0032169689

VL - 31

SP - 367

EP - 369

JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 3

ER -