A nöl nemi hormonok hatása a lymphocyta blastos transformatióra systhemás lupus erythematosusban és egészséges nökben.

Translated title of the contribution: Effect of female sex hormones on blastic transformation of lymphocytes in systemic lupus erythematosus and in healthy women

T. Pozsonyi, L. Jakab, R. Gonzalez-Cabello, V. V. Cao, K. Cseh, L. Kalabay, J. Marticsek, P. Gergely, L. Jakab

Research output: Contribution to journalReview article

Abstract

The susceptibility of women to autoimmune diseases is well-documented, of which systemic lupus erythematosus (SLE) is especially important. The use of oral contraceptives often activate SLE from a quiescent condition. The inductive effect of estrogen has been shown in animal studies indicating that female hormones can trigger autoimmune reaction. The effect of ethinyl estradiol, an estrogen (E), and d-norgestrel, a progesterone (P), on the mitogenic response of peripheral lymphocytes, and particularly on phytohemagglutinin (PHA)- and concanavalin-A (Con-A)-induced blastic transformation of lymphocytes (LBT) was studied in vitro. 25 patients with SLE and 27 healthy controls participated in the study. SLE was inactive in 16 patients, 7 took corticosteroids, and 3 also received 50 mg/day Imuran. 13 patients and 10 controls took contraceptives (Bisecurin, Infecundin, Ovidon, Rigevidon). The LBT value fell significantly in patients with active SLE, in contraceptive users, and the value was significantly lower in inactive patients than in those not using contraceptives. E and P separately or together significantly reduced LBT values. Contraceptives containing P only can be prescribed for women suffering from SLE, as its role in inducing the disease compared to E is negligible.

Original languageHungarian
Pages (from-to)2677-2678, 2681
JournalOrvosi hetilap
Volume128
Issue number51
Publication statusPublished - Dec 20 1987

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pozsonyi, T., Jakab, L., Gonzalez-Cabello, R., Cao, V. V., Cseh, K., Kalabay, L., Marticsek, J., Gergely, P., & Jakab, L. (1987). A nöl nemi hormonok hatása a lymphocyta blastos transformatióra systhemás lupus erythematosusban és egészséges nökben. Orvosi hetilap, 128(51), 2677-2678, 2681.