Effect of F-2 and T-2 fusariotoxins on experimental Cryptosporidium baileyi infection in chickens

L. Békési, S. Hornok, G. Szigeti, M. Dobos-Kovács, Z. Széll, I. Varga

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The course of Cryptosporidium baileyi infection in chickens fed with different doses of fusariotoxins was compared with that of control groups. F-2 toxin levels of 0.187-1.58 mg kg-1 and T-2 toxin levels of 0.187-6.0 mg kg-1 were investigated. The experimental animals were orally infected with 6 x 105 C. baileyi oocysts at 1 week of age. Total daily oocyst output was monitored by a quantitative method. Acquired immunity was tested at the age of 4 weeks, by ELISA and by a challenge infection with an equal number of oocysts, upon recovery from the primary infection. The results show that in chickens kept on the lower doses of F-2 and T-2 toxins, the parasite infection ran a similar course to that in the control groups, and the animals became resistant to re-infection. However, when higher doses (2.0-6.0 mg kg-1) of T-2 toxin were used, a depression of weight gain was observed with some other physiological parameters) (PCV, weight of bursa, weight of thymus, skin thickness in PHA-P skin test) also indicating toxic effect and, simultaneously, the oocyst output decreased significantly and the patent period was slightly prolonged. Although certain modifications of the immune response could be revealed, the chickens became resistant to re-infection. Only early (1 week of age) parasite infection and 6 mg kg-1 T-2 toxin in the feed significantly depressed body weight gain and immunity.

Original languageEnglish
Pages (from-to)1531-1536
Number of pages6
JournalInternational Journal for Parasitology
Volume27
Issue number12
DOIs
Publication statusPublished - Dec 1997

Keywords

  • Chickens
  • Cryptosporidium
  • Fusariotoxins

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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