Effect of excess selenium supplementation on the glutathione redox system in broiler chicken

K. Balogh, Mária Weber, Márta Erdélyi, M. Mézes

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Selenium, as part of selenocysteine, is the active centre of selenoenzymes. Excess amount of selenium generates oxygen free radicals and reacts with thiol compounds such as reduced glutathione, composing seleno-diglutathione. These reactions impair the amount and/or activity of the biological antioxidant defence system. In the present experiment the effects of two inorganic selenium sources (Na2SeO3, Na2SeO4) on lipid peroxidation and on the content and activity of some components of the antioxidant defence mechanism were studied in Ross 308 hybrid cockerels. In the tissues examined, the glutathione redox system was altered in different ways as an effect of excess selenium. The amount of glutathione and, consequently, glutathione peroxidase activity declined in the blood plasma and in the red blood cell haemolysate, while in the liver malondialdehyde concentration increased only at the end of the experimental period as a result of the boosted enzyme activity. The authors suppose that the cause of increased lipid peroxidation was the potential toxic effect of selenium accumulation above the actual demand.

Original languageEnglish
Pages (from-to)403-411
Number of pages9
JournalActa Veterinaria Hungarica
Volume52
Issue number4
DOIs
Publication statusPublished - 2004

Fingerprint

Selenium
selenium
Oxidation-Reduction
Glutathione
glutathione
Chickens
broiler chickens
Lipid Peroxidation
Ross (chicken breed)
lipid peroxidation
Antioxidants
antioxidant activity
Selenocysteine
selenocysteine
cockerels
Poisons
Glutathione Peroxidase
Malondialdehyde
thiols
blood plasma

Keywords

  • Broiler chicken
  • Glutathione redox system
  • Selenium
  • Toxicity

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effect of excess selenium supplementation on the glutathione redox system in broiler chicken. / Balogh, K.; Weber, Mária; Erdélyi, Márta; Mézes, M.

In: Acta Veterinaria Hungarica, Vol. 52, No. 4, 2004, p. 403-411.

Research output: Contribution to journalArticle

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