EUDRAGIT TIPUSU POLIMEREK HATOANYAGLEADAS SEBESSEGET BEFOLYASOLO HATASA LABORATORIUMI FLUIDIZACIOS ELJARASSAL ELOALLITOTT MAGNEZIUM-OXID TARTALMU SZEMCSEK ESETEN

Translated title of the contribution: Effect of Eudragit polymers on the drug release from magnesium oxide granules produced by laboratory fluidization

Research output: Contribution to journalArticle

Abstract

The differences in the bioavailability of different drug products are most frequently caused by differences in the dissolution rates of the active ingredient. In case of magnesium oxide the drug release can be directly determined by reaction kinetics method based on acid neutralization. It is reasonable to use homogeneous granule fractions for a more precise study of the factors influencing the pharmacokinetic parameters. These fractions can be produced favourably by fluidization granulation. It can be concluded from the results that the hydrophobization decreases the rate constant of neutralization. If the proportion of the polymer (insoluble in the neutralization medium) in the granules increases, the neutralization reaction slows down. The distribution of the film-forming polymer in the granules determined by the particle size significantly changes the neutralization reaction.

Original languageHungarian
Pages (from-to)543-545
Number of pages3
JournalGyogyszereszet
Volume39
Issue number7
Publication statusPublished - 1995

Fingerprint

Magnesium Oxide
Polymers
Particle Size
Biological Availability
Pharmacokinetics
Acids
Pharmaceutical Preparations
methylmethacrylate-methacrylic acid copolymer
Drug Liberation

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{63691fbcd9224b1c8b749ae45d788ba6,
title = "EUDRAGIT TIPUSU POLIMEREK HATOANYAGLEADAS SEBESSEGET BEFOLYASOLO HATASA LABORATORIUMI FLUIDIZACIOS ELJARASSAL ELOALLITOTT MAGNEZIUM-OXID TARTALMU SZEMCSEK ESETEN",
abstract = "The differences in the bioavailability of different drug products are most frequently caused by differences in the dissolution rates of the active ingredient. In case of magnesium oxide the drug release can be directly determined by reaction kinetics method based on acid neutralization. It is reasonable to use homogeneous granule fractions for a more precise study of the factors influencing the pharmacokinetic parameters. These fractions can be produced favourably by fluidization granulation. It can be concluded from the results that the hydrophobization decreases the rate constant of neutralization. If the proportion of the polymer (insoluble in the neutralization medium) in the granules increases, the neutralization reaction slows down. The distribution of the film-forming polymer in the granules determined by the particle size significantly changes the neutralization reaction.",
author = "R. Zelk{\'o}",
year = "1995",
language = "Hungarian",
volume = "39",
pages = "543--545",
journal = "Gyogyszereszet",
issn = "0017-6036",
publisher = "Magyar Gyogyszereszeti Tarsasag",
number = "7",

}

TY - JOUR

T1 - EUDRAGIT TIPUSU POLIMEREK HATOANYAGLEADAS SEBESSEGET BEFOLYASOLO HATASA LABORATORIUMI FLUIDIZACIOS ELJARASSAL ELOALLITOTT MAGNEZIUM-OXID TARTALMU SZEMCSEK ESETEN

AU - Zelkó, R.

PY - 1995

Y1 - 1995

N2 - The differences in the bioavailability of different drug products are most frequently caused by differences in the dissolution rates of the active ingredient. In case of magnesium oxide the drug release can be directly determined by reaction kinetics method based on acid neutralization. It is reasonable to use homogeneous granule fractions for a more precise study of the factors influencing the pharmacokinetic parameters. These fractions can be produced favourably by fluidization granulation. It can be concluded from the results that the hydrophobization decreases the rate constant of neutralization. If the proportion of the polymer (insoluble in the neutralization medium) in the granules increases, the neutralization reaction slows down. The distribution of the film-forming polymer in the granules determined by the particle size significantly changes the neutralization reaction.

AB - The differences in the bioavailability of different drug products are most frequently caused by differences in the dissolution rates of the active ingredient. In case of magnesium oxide the drug release can be directly determined by reaction kinetics method based on acid neutralization. It is reasonable to use homogeneous granule fractions for a more precise study of the factors influencing the pharmacokinetic parameters. These fractions can be produced favourably by fluidization granulation. It can be concluded from the results that the hydrophobization decreases the rate constant of neutralization. If the proportion of the polymer (insoluble in the neutralization medium) in the granules increases, the neutralization reaction slows down. The distribution of the film-forming polymer in the granules determined by the particle size significantly changes the neutralization reaction.

UR - http://www.scopus.com/inward/record.url?scp=0029166711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029166711&partnerID=8YFLogxK

M3 - Article

VL - 39

SP - 543

EP - 545

JO - Gyogyszereszet

JF - Gyogyszereszet

SN - 0017-6036

IS - 7

ER -