Effect of ethyldeoxyuridine on 5-fluorouracil-induced neutropenia

A. Megyeri, I. Benkö, A. Jeney, J. Kralovánszky, P. Kovács

Research output: Contribution to journalArticle

Abstract

It is supposed that the toxic effect of 5-fluorouracil (5FU) on tumour cells may be increased by pretreatment with ethyldeoxyuridine (EDU). We studied the effect of this combination on neutrophil count in mice. Our present studies demonstrated that the neutropenia induced by 5×20 mg/kg 5FU became more severe when each dose of 5FU was preceded by 200 mg/kg EDU.

Original languageEnglish
Pages (from-to)309-310
Number of pages2
JournalActa physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - Dec 1 1996

Keywords

  • 5-fluorouracil
  • Ethyldeoxyuridine
  • Mouse
  • Neutropenia

ASJC Scopus subject areas

  • Physiology (medical)

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  • Cite this

    Megyeri, A., Benkö, I., Jeney, A., Kralovánszky, J., & Kovács, P. (1996). Effect of ethyldeoxyuridine on 5-fluorouracil-induced neutropenia. Acta physiologica Hungarica, 84(3), 309-310.