Effect of epidermal growth factor (EGF) on Tetrahymena pyriformis

L. Kőhidai, Márk Keresztesi, G. Csaba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Tetrahymena has receptors for hormones characteristic in higher animals and signal transduction systems for provoking response. In the present experiments EGF, a potent mitogen of epithelial cells were studied. In a 24 h experiment 1 h treatment with different concentrations of EGF (0.1-10 μg) significantly decreased the growth of Tetrahymena. Five microgram EGF treatment 24 h after 5 μg EGF pretreatment (imprinting) also significantly reduced the amount of cells, and this was moderately, however significantly less, than without the repeated treatment. After 48 h there was not difference between the amount of single or double treated cells. EGF was chemorepellent in chemotaxis experiments and 4 h EGF pretreatment abolished this effect, possibly by down regulation. The experiments call attention to the effect of EGF at a very low phylogenetic level, however the direction of the effect was the opposite of the effect in higher animals.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalActa Protozoologica
Volume40
Issue number3
Publication statusPublished - 2001

Fingerprint

Tetrahymena pyriformis
epidermal growth factor
Epidermal Growth Factor
Tetrahymena
pretreatment
chemotaxis
hormone receptors
Chemotaxis
Mitogens
signal transduction
Signal Transduction
animals
epithelial cells
Therapeutics
Down-Regulation
Epithelial Cells
Hormones
cells
phylogeny
Growth

Keywords

  • Cell growth
  • Chemotaxis
  • Evolution
  • Growth factors
  • Tetrahymena

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Microbiology

Cite this

Effect of epidermal growth factor (EGF) on Tetrahymena pyriformis. / Kőhidai, L.; Keresztesi, Márk; Csaba, G.

In: Acta Protozoologica, Vol. 40, No. 3, 2001, p. 221-224.

Research output: Contribution to journalArticle

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