Effect of endotoxin administration on the severity of acute pancreatitis in two experimental models

József Pozsár, Richard Schwab, Károly Simon, László Fekete, György Orgován, Ákos Pap

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Conclusions. Endotoxemia can transform acute pancreatitis (AP) into a more severe form of the disease in models of AP provoked by common pancreatico-biliary duct ligation or L-arginine injection. Background. It has been shown that systemic endotoxemia is a common feature in severe AP. The effect of endotoxemia on the course of experimental pancreatitis is unknown. Methods. AP was induced by common pancreatico-biliary duct ligation (experiment 1) and ip injection of 250 mg/100 g body wt of L-arginine (experiment 2). Test animals of both experiments received ip injections of 0.5 and 1.0 mg/100 g body wt of endotoxin at the induction of AP. Saline- treated and only endotoxin-dosed animals served as controls for both experiments. Mortality rates and pancreatic histology were investigated at 48 h. Results. The mortality rate was significantly elevated (60%, p < 0.05) in experiment 1 when 1.0 mg/100 g of endotoxin was given. In experiment 2, the mortality rate was also increased (30%) at this dose of endotoxin without reaching significance. Histologic changes were more severe in both groups of AP treated by the two doses of endotoxin than without it. Acinar necrosis and hemorrhage were highly elevated (p < 0.01) in both experiments when AP was combined with 1.0 mg/100 g body wt of endotoxin. The animals receiving only endotoxin showed only slight inflammatory and necrotic changes.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalInternational Journal of Pancreatology
Issue number1
Publication statusPublished - Dec 1 1997



  • Acute pancreatitis
  • Duct ligation
  • Endotoxin
  • L-arginine
  • Rat

ASJC Scopus subject areas

  • Oncology
  • Endocrinology
  • Gastroenterology

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