Effect of endotoxin administration on the severity of acute pancreatitis in two experimental models

József Pozsár, Richard Schwab, Károly Simon, László Fekete, György Orgován, A. Pap

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Conclusions: Endotoxemia can transform acute pancreatitis (AP) into a more severe form of the disease in models of AP provoked by common pancreatico-biliary duct ligation or l-arginine injection. Background: It has been shown that systemic endotoxemia is a common feature in severe AP. The effect of endotoxemia on the course of experimental pancreatitis is unknown. Methods: AP was induced by common pancreatico-biliary duct ligation (experiment 1) and ip injection of 250 mg/100 g body wt of l-arginine (experiment 2). Test animals of both experiments received ip injections of 0.5 and 1.0 mg/100 g body wt of endotoxin at the induction of AP. Saline-treated and only endotoxin-dosed animals served as controls for both experiments. Mortality rates and pancreatic histology were investigated at 48 h. Results: The mortality rate was significantly elevated (60%, p

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalInternational Journal of Gastrointestinal Cancer
Volume22
Issue number1
DOIs
Publication statusPublished - Aug 1997

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Endotoxins
Pancreatitis
Theoretical Models
Endotoxemia
Injections
Ligation
Arginine
Mortality
Histology

Keywords

  • Acute pancreatitis
  • duct ligation
  • endotoxin
  • l-arginine
  • rat

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

Cite this

Effect of endotoxin administration on the severity of acute pancreatitis in two experimental models. / Pozsár, József; Schwab, Richard; Simon, Károly; Fekete, László; Orgován, György; Pap, A.

In: International Journal of Gastrointestinal Cancer, Vol. 22, No. 1, 08.1997, p. 31-37.

Research output: Contribution to journalArticle

Pozsár, József ; Schwab, Richard ; Simon, Károly ; Fekete, László ; Orgován, György ; Pap, A. / Effect of endotoxin administration on the severity of acute pancreatitis in two experimental models. In: International Journal of Gastrointestinal Cancer. 1997 ; Vol. 22, No. 1. pp. 31-37.
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