Effect of endolymphatic hydrops on capsaicin-evoked increase in cochlear blood flow

Z. Vass, P. Bradley Brechtelsbauer, Alfred I. Nuttall, Josef M. Miller

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Capsaicin, which causes release of neuropeptides including substance P, has been shown to cause dose-related increases in cochlear blood flow (CBF). Since CBF regulation is altered in animal models with endolymphatic hydrops, this study was designed to examine the effect of hydrops on capsaicin-induced CBF changes. CBF responses to 0.01 and 0.001% capsaicin applied to the round window membrane were measured in normal and 12-week hydropic guinea pigs using laser Doppler flowmetry. With 0.01% capsaicin, CBF increased by only 13± 7.8% in the hydropic ear, compared with 34% ± 13% in the normal animal (p=0.027). With 0.001% capsaicin, CBF increased by only 7.5 ± 4.2% in the hydropic ear, compared with 28 ± 16% in the normal ear (p

Original languageEnglish
Pages (from-to)754-758
Number of pages5
JournalActa Oto-Laryngologica
Volume115
Issue number2
DOIs
Publication statusPublished - 1995

Fingerprint

Endolymphatic Hydrops
Capsaicin
Cochlea
Edema
Ear
Laser-Doppler Flowmetry
Substance P
Neuropeptides
Guinea Pigs
Animal Models
Membranes

Keywords

  • Guinea pig
  • Inner ear
  • Laser Doppler flowmetry
  • Microcirculation
  • Sensory neurons

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Effect of endolymphatic hydrops on capsaicin-evoked increase in cochlear blood flow. / Vass, Z.; Brechtelsbauer, P. Bradley; Nuttall, Alfred I.; Miller, Josef M.

In: Acta Oto-Laryngologica, Vol. 115, No. 2, 1995, p. 754-758.

Research output: Contribution to journalArticle

Vass, Z. ; Brechtelsbauer, P. Bradley ; Nuttall, Alfred I. ; Miller, Josef M. / Effect of endolymphatic hydrops on capsaicin-evoked increase in cochlear blood flow. In: Acta Oto-Laryngologica. 1995 ; Vol. 115, No. 2. pp. 754-758.
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