Effect of emetine and chloroquine on phagocytic processes of rat macrophages

Ferenc Antoni, A. Hrabák, Ildikó Csuka

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Emetine and chloroquine caused a dose-dependent and time-dependent inhibition of bacterial phagocytosis in rat peritoneal macrophages. The effect of emetine was found to be stronger: 50% inhibition was achieved at 5 × 10-6 M concentration. The inhibition of phagocytosis was irreversible. Neither the binding of bacteria to the surface of phagocytes nor membrane marker 5' nucleotidase was touched by this treatment. The adherence of macrophages to plastic dishes was also impaired by the drugs but only in a smaller extent. Both emetine and chloroquine blocked the amino acid incorporation into macrophage proteins. The effect of emetine was more marked; 10-6 M decreased the incorporation to 25% of control, while 10-4 M chloroquine produced a similar inhibition. The block of protein synthesis was also irreversible.

Original languageEnglish
Pages (from-to)2869-2874
Number of pages6
JournalBiochemical Pharmacology
Volume35
Issue number17
DOIs
Publication statusPublished - Sep 1 1986

Fingerprint

Emetine
Macrophages
Chloroquine
Rats
Phagocytosis
5'-Nucleotidase
Peritoneal Macrophages
Phagocytes
Plastics
Bacteria
Proteins
Membranes
Amino Acids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of emetine and chloroquine on phagocytic processes of rat macrophages. / Antoni, Ferenc; Hrabák, A.; Csuka, Ildikó.

In: Biochemical Pharmacology, Vol. 35, No. 17, 01.09.1986, p. 2869-2874.

Research output: Contribution to journalArticle

Antoni, Ferenc ; Hrabák, A. ; Csuka, Ildikó. / Effect of emetine and chloroquine on phagocytic processes of rat macrophages. In: Biochemical Pharmacology. 1986 ; Vol. 35, No. 17. pp. 2869-2874.
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