Effect of electrical stimulation of the neurohypophysis on ACTH release in rats with hypothalamic lesions

G. Makara, E. Stark, M. Kárteszi, E. Fellinger, G. Rappav, D. Szabó

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Electrical stimulation of the neural lobe (NL) of the pituitary induces a rise in plasma corticosterone indicating the release of adrenocorticotropin (ACTH) in rats pretreated with dexamethasone, morphine and pentobarbitone. 7–8 days after placing an anterolateral cut around the medial basal hypothalamus (MBH), the rats failed to respond with ACTH release to electrical stimulation of the NL; the number of nerve fibers and terminals in the NL decreased to less than 5% of the normal; and ACTH releasing activity of acid extracts of the NL was undetectable using both in vivo and in vitro tests, which are insensitive to vasopressin. After lesions of the paraventricular nuclei the stimulation of the NL elicited a rise of plasma corticosterone that was significantly less than that in the controls. These results suggest that the NL of the pituitary contains electrically excitable fibers capable of releasing corticotropin-releasing factor (CRF; distinct from vasopressin) and that these fibers probably originate from outside the MBH, witha portion of them coming from or through the paraventricular nuclei or their immediate vicinity.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalNeuroendocrinology
Volume31
Issue number4
DOIs
Publication statusPublished - 1980

Fingerprint

Posterior Pituitary Gland
Adrenocorticotropic Hormone
Electric Stimulation
Middle Hypothalamus
Paraventricular Hypothalamic Nucleus
Corticosterone
Vasopressins
Corticotropin-Releasing Hormone
Pentobarbital
Nerve Fibers
Morphine
Dexamethasone
Acids

Keywords

  • ACTH
  • Corticotrophin-relcasing factor
  • Electrical stimulation
  • Hypothalamic lesion
  • Neurohypophysis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Effect of electrical stimulation of the neurohypophysis on ACTH release in rats with hypothalamic lesions. / Makara, G.; Stark, E.; Kárteszi, M.; Fellinger, E.; Rappav, G.; Szabó, D.

In: Neuroendocrinology, Vol. 31, No. 4, 1980, p. 237-243.

Research output: Contribution to journalArticle

Makara, G. ; Stark, E. ; Kárteszi, M. ; Fellinger, E. ; Rappav, G. ; Szabó, D. / Effect of electrical stimulation of the neurohypophysis on ACTH release in rats with hypothalamic lesions. In: Neuroendocrinology. 1980 ; Vol. 31, No. 4. pp. 237-243.
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