Effect of elastin peptides on human monocytes: Ca2+ mobilization, stimulation of respiratory burst and enzyme secretion

T. Fülöp, M. P. Jacob, Zs Varga, G. Foris, A. Leovey, L. Robert

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The effect of elastinpeptides (Kappa-elastin) was investigated on human monocytes. The data presented here indicate that elastin peptides increase the intracellular Ca2+ level measured by Quin 2 fluorescence and mediate the release of B glucuronidase and elastase.The O2 consumption and H2O2 release were stimulated in a dose- dependent manner. The early rise of cAMP was followed by a return to the original level at 30 min and by a concomittant increase of cGMP level. The action of elastin peptides on intracellular calcium level and cGMP levels may well be related to itspreviously demonstrated chemotactic activity. These activities may well play a role in the modifications of the extracellular matrix following elastin degradation as observed inatheroscierosis emphysema and aging.

Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalBiochemical and biophysical research communications
Volume141
Issue number1
DOIs
Publication statusPublished - Nov 26 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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