Effect of elastin peptides and N-formyl-methionyl-leucyl phenylalanine on cytosolic free calcium in polymorphonuclear leukocytes of healthy middle-aged and elderly subjects

Zsuzsa Varga, Éva M. Kovács, György Paragh, Marie Paule Jacob, Ladislas Robert, Tamás Fülöp

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Abstract

The effect of elastin peptides (kappa-elastin, KE) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) on cytosolic free calcium in polymorphonuclear leukocytes (PMNLs) of healthy middle-aged (35-45 years) and elderly (>60 years) patients with normal and high serum cholesterol level was investigated. The cytosolic free calcium ([Ca2+]iti) elevation after stimulation with these compounds was decreased in PMNLs of the aged groups compared to the healthy middle-aged group. The guanine nucleotide binding regulatory Giti protein inhibitor, pertussis toxin (PT) prevented the enhancing effect of KE and FMLP on PMNL free calcium of healthy middle-aged subjects, but could not completely abolish the [Ca2+]iti elevation in PMNLs of aged subjects.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalClinical Biochemistry
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 1988

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Keywords

  • aging
  • chemotactic peptide
  • cytosolic free calcium
  • elastin peptides
  • polymorphonuclear leukocytes

ASJC Scopus subject areas

  • Clinical Biochemistry

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