Effect of duration and frequency of stimulation on the presynaptic inhibition by α-adrenoceptor stimulation of the adrenergic transmission

E. Vízi, G. T. Somogyi, P. Hadházy, J. Knoll

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

It had been shown previously that in rat vas deferens prostaglandins fail to influence neurochemical transmission. Therefore, this preparation provides a possibility for studying the transmitter release in a preparation in which any interaction with prostaglandins was in all likelihood excluded. 1. The inhibitory effect of α-adrenoceptor stimulation by either noradrenaline, BAY-1470 or clonidine on the response of rat vas deferens and guinea-pig atria to field stimulation depended on the rate of stimulation and on the length of train applied. The higher the frequency and the longer the train the smaller was the inhibition. 2. Direct evidence for the presynaptic inhibitory effect of α-adrenoceptor stimulation on transmitter release has also been provided by measuring the release of 3H-noradrenaline; there was a reduction at 2 Hz stimulation, but not at 50 Hz.

Original languageEnglish
Pages (from-to)79-91
Number of pages13
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume280
Issue number1
DOIs
Publication statusPublished - Mar 1973

Fingerprint

Vas Deferens
Adrenergic Agents
Adrenergic Receptors
Prostaglandins
Norepinephrine
Clonidine
Guinea Pigs

Keywords

  • Frequency Dependence
  • Guinea-Pig Atrium
  • Noradrenergic Transmission-α-Adrenoceptors
  • Presynaptic Inhibition
  • Tritriated Noradenaline Release
  • Vas deferens

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{0bca51bceaf24c88895fc9d97120bb72,
title = "Effect of duration and frequency of stimulation on the presynaptic inhibition by α-adrenoceptor stimulation of the adrenergic transmission",
abstract = "It had been shown previously that in rat vas deferens prostaglandins fail to influence neurochemical transmission. Therefore, this preparation provides a possibility for studying the transmitter release in a preparation in which any interaction with prostaglandins was in all likelihood excluded. 1. The inhibitory effect of α-adrenoceptor stimulation by either noradrenaline, BAY-1470 or clonidine on the response of rat vas deferens and guinea-pig atria to field stimulation depended on the rate of stimulation and on the length of train applied. The higher the frequency and the longer the train the smaller was the inhibition. 2. Direct evidence for the presynaptic inhibitory effect of α-adrenoceptor stimulation on transmitter release has also been provided by measuring the release of 3H-noradrenaline; there was a reduction at 2 Hz stimulation, but not at 50 Hz.",
keywords = "Frequency Dependence, Guinea-Pig Atrium, Noradrenergic Transmission-α-Adrenoceptors, Presynaptic Inhibition, Tritriated Noradenaline Release, Vas deferens",
author = "E. V{\'i}zi and Somogyi, {G. T.} and P. Hadh{\'a}zy and J. Knoll",
year = "1973",
month = "3",
doi = "10.1007/BF00505357",
language = "English",
volume = "280",
pages = "79--91",
journal = "Naunyn-Schmiedeberg's Archives of Pharmacology",
issn = "0028-1298",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Effect of duration and frequency of stimulation on the presynaptic inhibition by α-adrenoceptor stimulation of the adrenergic transmission

AU - Vízi, E.

AU - Somogyi, G. T.

AU - Hadházy, P.

AU - Knoll, J.

PY - 1973/3

Y1 - 1973/3

N2 - It had been shown previously that in rat vas deferens prostaglandins fail to influence neurochemical transmission. Therefore, this preparation provides a possibility for studying the transmitter release in a preparation in which any interaction with prostaglandins was in all likelihood excluded. 1. The inhibitory effect of α-adrenoceptor stimulation by either noradrenaline, BAY-1470 or clonidine on the response of rat vas deferens and guinea-pig atria to field stimulation depended on the rate of stimulation and on the length of train applied. The higher the frequency and the longer the train the smaller was the inhibition. 2. Direct evidence for the presynaptic inhibitory effect of α-adrenoceptor stimulation on transmitter release has also been provided by measuring the release of 3H-noradrenaline; there was a reduction at 2 Hz stimulation, but not at 50 Hz.

AB - It had been shown previously that in rat vas deferens prostaglandins fail to influence neurochemical transmission. Therefore, this preparation provides a possibility for studying the transmitter release in a preparation in which any interaction with prostaglandins was in all likelihood excluded. 1. The inhibitory effect of α-adrenoceptor stimulation by either noradrenaline, BAY-1470 or clonidine on the response of rat vas deferens and guinea-pig atria to field stimulation depended on the rate of stimulation and on the length of train applied. The higher the frequency and the longer the train the smaller was the inhibition. 2. Direct evidence for the presynaptic inhibitory effect of α-adrenoceptor stimulation on transmitter release has also been provided by measuring the release of 3H-noradrenaline; there was a reduction at 2 Hz stimulation, but not at 50 Hz.

KW - Frequency Dependence

KW - Guinea-Pig Atrium

KW - Noradrenergic Transmission-α-Adrenoceptors

KW - Presynaptic Inhibition

KW - Tritriated Noradenaline Release

KW - Vas deferens

UR - http://www.scopus.com/inward/record.url?scp=34250431601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250431601&partnerID=8YFLogxK

U2 - 10.1007/BF00505357

DO - 10.1007/BF00505357

M3 - Article

VL - 280

SP - 79

EP - 91

JO - Naunyn-Schmiedeberg's Archives of Pharmacology

JF - Naunyn-Schmiedeberg's Archives of Pharmacology

SN - 0028-1298

IS - 1

ER -