Effect of drugs used in different type of myocardial infarction (STEMI or NSTEMI) on mortality

Zoltan Vincze, B. Brugos, I. Lorincz, G. Paragh

Research output: Contribution to journalArticle

Abstract

We examined 416 patients with acutemyocardial infarction. 249 patients had STEMI and 167 NSTEMI. 227 were men and 189 women. 142 men had STEMI and 85 men had NSTEMI. 107 women were diagnosed with STEMI and 82 with NSTEMI. 22.5% of patient with STEMI and 20.2% of patients with NSTEMI died (p = 0.58). We compared the effect of anticoagulant treatment, clopidogrel, salicylate, nitrate, beta-blocker, angiotensin-converting enzyme inhibitor, statin and trimetazidine therapy on mortality in function of the type of myocardial infarction. There were no differences between mortality of patients with STEMI and NSTEMI with respect of use of heparine, salicylate, nitrate, beta-blocker, ACE inhibitor, statin and trimetazidine. While examining the effect of clopidogrel, we observed a significantly lower mortality rate in patients with NSTEMI compared to the STEMI group (p = 0.005). These differences are due to the known variability in clopidogrel absorption and metabolism, which could be influenced by the type of myocardial infarction.

Original languageEnglish
Pages (from-to)445-447
Number of pages3
JournalPharmazie
Volume69
Issue number6
DOIs
Publication statusPublished - Jun 2014

ASJC Scopus subject areas

  • Pharmaceutical Science

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