Effect of dopexamine hydrochloride in the early stages of experimental myocardial infarction and comparison with dopamine and dobutamine

J. Parratt, Cherry L. Wainwright, Olu Fagbemi

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Abstract

The effect of dopexamine hydrochloride on myocardial performance, and on the susceptibility of the myocardium to generation of arrhythmias during the development of myocardial infarction has been compared with dopamine and dobutamine in 2 experimental models of myocardial ischemia. All 3 agents improved cardiac function in the presence of a developing infarct. Dopamine and dobutamine increased myocardial contractility (left ventricular dP/dt and left ventricular dP/dt/P), which would be expected to increase oxygen consumption and thus further compromise the ischemic myocardium. Dopexamine hydrochloride, however, improved cardiac function mainly by reducing afterload. The infusion of dopamine and dobutamine resulted in a high (100%) incidence of ventricular arrhythmias compared with only 63% with dopexamine hydrochloride. The effects of these agents on early ischemic arrhythmias after coronary artery ligation in anesthetized rats were also studied. Dopexamine hydrochloride reduced the incidence and severity of arrhythmias in the early stages of ischemia: At a dose of 0.25 μg/Kg/min, the total number of ectopic beats was reduced to 375 ± 175, from 1,250 ± 330 in control rats (p

Original languageEnglish
JournalThe American journal of cardiology
Volume62
Issue number5
DOIs
Publication statusPublished - Aug 11 1988

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Dobutamine
Cardiac Arrhythmias
Dopamine
Myocardial Infarction
Myocardium
Incidence
Oxygen Consumption
Myocardial Ischemia
Ligation
Coronary Vessels
Theoretical Models
Ischemia
dopexamine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Effect of dopexamine hydrochloride in the early stages of experimental myocardial infarction and comparison with dopamine and dobutamine. / Parratt, J.; Wainwright, Cherry L.; Fagbemi, Olu.

In: The American journal of cardiology, Vol. 62, No. 5, 11.08.1988.

Research output: Contribution to journalArticle

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