Dopaminerg és szerotonerg génvariánsok hatása a kognitív teljesítményre

Translated title of the contribution: Effect of dopaminergic and serotonergic gene variants on cognitive performance

Katonai Eniko Rózsa, A. Székely, M. Sasvári

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

According to twin studies heritability of cognitive skills is substantial, however, little is known about the gene variants responsible for coding individual variability. Results of candidate gene studies implicate an important role of the dopaminergic system in coding individual differences in reaction time performance, and the possible role of the function of the serotonergic system has also emerged. Goals: The aim of our study was to carry out association analyses between performance on the Stroop-task and selected gene polymorphisms of the dopaminergic and serotonergic system. Results: In this study we examined 179 young adult's Stroop-performance measuring the attentional inhibition. The number of mistakes showed remarkable individual variability which can be related to the polymorphisms of the dopamine D4 receptor gene according to several previous studies. The short and long variations of the variable number tandem repeat polymorphism in the promoter region of the serotonin transporter gene was also studied based on the hypothesis of dopamine-serotonin balance. Conclusion: Our results demonstrate that the performance in the Stroop task is related to the genetic variants of the dopaminergic, as well as the serotonergic system.

Original languageHungarian
Pages (from-to)81-86
Number of pages6
JournalNeuropsychopharmacologia Hungarica
Volume13
Issue number2
Publication statusPublished - Jun 2011

Fingerprint

Genes
Dopamine D4 Receptors
Serotonin Plasma Membrane Transport Proteins
Minisatellite Repeats
Twin Studies
Genetic Promoter Regions
Individuality
Reaction Time
Young Adult
Dopamine
Serotonin
Inhibition (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

Dopaminerg és szerotonerg génvariánsok hatása a kognitív teljesítményre. / Rózsa, Katonai Eniko; Székely, A.; Sasvári, M.

In: Neuropsychopharmacologia Hungarica, Vol. 13, No. 2, 06.2011, p. 81-86.

Research output: Contribution to journalArticle

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