Effect of dopamine on the inward membrane currents of the sinoauricular fibers of the frog heart

K. Kelmen, R. Marko, V. Kecskemeti

Research output: Contribution to journalArticle

Abstract

Dopamine increased the slow inward current in the cardiac preparation after blocking (with tetrodotoxin) or eliminating (with Na+-free perfusion) of the 'fast Na+ channel'. Dopamine was, however, ineffective, if the 'slow channel' was blocked (by MnCl2 or D-600) or eliminated (by Ca2+ free perfusion). This adrenaline-like effect of dopamine was prevented by beta-adrenergic blockade (pindolol) and was not modified by previous depletion of tissue catecholamine stores (pretreatment with reserpine). Our data suggest that dopamine affects cardiac electrogenesis through beta-adrenergic receptors and any dopamine-induced noradrenaline release may be only of secondary importance beside this direct agonistic effect.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalPolish journal of pharmacology and pharmacy
Volume37
Issue number3
Publication statusPublished - Dec 1 1985

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Effect of dopamine on the inward membrane currents of the sinoauricular fibers of the frog heart'. Together they form a unique fingerprint.

  • Cite this