Effect of DNA polymerase inhibitors on the replication of human cytomegalovirus

E. Gönczöl, S. A. Plotkin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aphidicolin, a specific inhibitor of cellular DNA polymerase α and of viral DNA polymerase, inhibits production of infectious virus and cellular and viral DNA synthesis of human cytomegalovirus (HCMV)-infected cells. On the other hand, 2′, 3′-dideoxynucleosides, inhibitors of DNA polymerases β and γ, do not affect HCMV replication. The data show that the α DNA polymerases of either viral or cellular origin are required for viral DNA synthesis, and cannot be substituted by the cellular DNA polymerase β and γ.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalArchives of virology
Volume84
Issue number1-2
DOIs
Publication statusPublished - Mar 1 1985

ASJC Scopus subject areas

  • Virology

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