Effect of different statins on the antifungal activity of polyene antimycotics

Ildikó Nyilasi, Sándor Kocsubé, László Galgóczy, Tamás Papp, Miklós Pesti, Csaba Vágvölgyi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The antifungal activities of amphotericin B/statin and nystatin/statin combinations against some opportunistic pathogenic fungi (Candida albicans, Candida glabrata, Paecilomyces variotii, Aspergillus fumigatus, Aspergillus flavus and Rhizopus oryzae) were investigated. The in vitro interactions between polyene antifungal drugs and different statins were evaluated using a standard chequerboard broth microdilution method. Most of the detected interactions were additive, though in some cases synergism was also observed. In most cases, the extents of inhibition were higher when these compounds were applied together, and as a result the concentrations of amphotericin B and a given statin, needed to prevent fungal growth, generally could be decreased by some dilution steps.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalActa Biologica Szegediensis
Volume54
Issue number1
Publication statusPublished - Oct 12 2010

Keywords

  • Amphotericin B
  • Drug interaction
  • Microscopic fungi
  • Nystatin
  • Statins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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