Effect of different cytostatic protocols on oncogene expression in CBA/Ca mice

I. Ember, T. Raposa, C. Varga, I. Kiss

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In vivo investigations on oncogene action may provide new findings on the toxicology of potential carcinogens. In this study we investigated the early effects of different cytostatic protocols on early oncogene expression in CBA/Ca mice. Most of the examined protocols showed detectable early changes, especially those containing cyclophosphamide. The most frequently involved oncogenes were N-ras, c-myc, and c-myb.

Original languageEnglish
Pages (from-to)1285-1288
Number of pages4
JournalAnticancer research
Volume15
Issue number4
Publication statusPublished - Jan 1 1995

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Keywords

  • CBA/Ca mice
  • Carcinogenicity
  • Cytostatic protocol
  • Oncogene expression
  • Secondary tumors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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