Effect of dietary restriction beyond middle age: Accumulation of altered proteins and protein degradation

Ryoya Takahashi, S. Goto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Dietary restriction (DR) from weaning or young adult stages in rodents throughout their usual life span has been shown to prolong longevity and lower or delay (or both) the occurrence of many late-onset diseases, but the effects of DR when performed at middle age or later have not been well investigated. We have studied the effect of DR initiated late in life on altered proteins and protein degradation. DR initiated in 23.5-month-old mice and continued for 2 months reduced the amount of altered proteins and shortened the half-life of proteins, including oxidatively modified ones. Furthermore, our more recent studies in rats demonstrated that DR initiated later in life (26.5 months old) restored the activities of proteasomes that have been implicated in removal of altered proteins. Thus, DR initiated even relatively late in life appears to have beneficial effects, restoring an animal's youthful condition in terms of the age-related accumulation of altered proteins.

Original languageEnglish
Pages (from-to)278-281
Number of pages4
JournalMicroscopy Research and Technique
Volume59
Issue number4
DOIs
Publication statusPublished - Nov 15 2002

Fingerprint

dietary restriction
protein degradation
Proteolysis
constrictions
degradation
proteins
Proteins
Degradation
life span
Proteasome Endopeptidase Complex
rodents
Weaning
proteasome endopeptidase complex
Half-Life
Young Adult
Rodentia
young adults
half life
rats
mice

Keywords

  • Adult-onset
  • Caloric restriction
  • Heat-labile enzyme
  • Proteasome
  • Ubiquitin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Effect of dietary restriction beyond middle age : Accumulation of altered proteins and protein degradation. / Takahashi, Ryoya; Goto, S.

In: Microscopy Research and Technique, Vol. 59, No. 4, 15.11.2002, p. 278-281.

Research output: Contribution to journalArticle

@article{c4525ba4e33a401aabb250d95ea98d42,
title = "Effect of dietary restriction beyond middle age: Accumulation of altered proteins and protein degradation",
abstract = "Dietary restriction (DR) from weaning or young adult stages in rodents throughout their usual life span has been shown to prolong longevity and lower or delay (or both) the occurrence of many late-onset diseases, but the effects of DR when performed at middle age or later have not been well investigated. We have studied the effect of DR initiated late in life on altered proteins and protein degradation. DR initiated in 23.5-month-old mice and continued for 2 months reduced the amount of altered proteins and shortened the half-life of proteins, including oxidatively modified ones. Furthermore, our more recent studies in rats demonstrated that DR initiated later in life (26.5 months old) restored the activities of proteasomes that have been implicated in removal of altered proteins. Thus, DR initiated even relatively late in life appears to have beneficial effects, restoring an animal's youthful condition in terms of the age-related accumulation of altered proteins.",
keywords = "Adult-onset, Caloric restriction, Heat-labile enzyme, Proteasome, Ubiquitin",
author = "Ryoya Takahashi and S. Goto",
year = "2002",
month = "11",
day = "15",
doi = "10.1002/jemt.10205",
language = "English",
volume = "59",
pages = "278--281",
journal = "Microscopy Research and Technique",
issn = "1059-910X",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Effect of dietary restriction beyond middle age

T2 - Accumulation of altered proteins and protein degradation

AU - Takahashi, Ryoya

AU - Goto, S.

PY - 2002/11/15

Y1 - 2002/11/15

N2 - Dietary restriction (DR) from weaning or young adult stages in rodents throughout their usual life span has been shown to prolong longevity and lower or delay (or both) the occurrence of many late-onset diseases, but the effects of DR when performed at middle age or later have not been well investigated. We have studied the effect of DR initiated late in life on altered proteins and protein degradation. DR initiated in 23.5-month-old mice and continued for 2 months reduced the amount of altered proteins and shortened the half-life of proteins, including oxidatively modified ones. Furthermore, our more recent studies in rats demonstrated that DR initiated later in life (26.5 months old) restored the activities of proteasomes that have been implicated in removal of altered proteins. Thus, DR initiated even relatively late in life appears to have beneficial effects, restoring an animal's youthful condition in terms of the age-related accumulation of altered proteins.

AB - Dietary restriction (DR) from weaning or young adult stages in rodents throughout their usual life span has been shown to prolong longevity and lower or delay (or both) the occurrence of many late-onset diseases, but the effects of DR when performed at middle age or later have not been well investigated. We have studied the effect of DR initiated late in life on altered proteins and protein degradation. DR initiated in 23.5-month-old mice and continued for 2 months reduced the amount of altered proteins and shortened the half-life of proteins, including oxidatively modified ones. Furthermore, our more recent studies in rats demonstrated that DR initiated later in life (26.5 months old) restored the activities of proteasomes that have been implicated in removal of altered proteins. Thus, DR initiated even relatively late in life appears to have beneficial effects, restoring an animal's youthful condition in terms of the age-related accumulation of altered proteins.

KW - Adult-onset

KW - Caloric restriction

KW - Heat-labile enzyme

KW - Proteasome

KW - Ubiquitin

UR - http://www.scopus.com/inward/record.url?scp=0037111857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037111857&partnerID=8YFLogxK

U2 - 10.1002/jemt.10205

DO - 10.1002/jemt.10205

M3 - Article

C2 - 12424789

AN - SCOPUS:0037111857

VL - 59

SP - 278

EP - 281

JO - Microscopy Research and Technique

JF - Microscopy Research and Technique

SN - 1059-910X

IS - 4

ER -