Effect of dialysable leukocyte extracts on antibody-dependent cellular cytotoxicity and lymphocyte Fc receptors

L. Nekam, I. Láng, B. Fekete

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Abstract

Dialysable leukocyte extracts significantly inhibited the antibody-dependent cell-mediated cytotoxicity of normal human peripheral blood lymphocytes in both xenogeneic and allogeneic assays. The inhibitory effect was dose-dependent. Fractions of dialysable leukocyte extracts separated on Sephadex G-25 column differed in their capacity to suppress cytotoxicity. Dialysable leukocyte extracts did not block EA-rosetting but inhibited the resynthesis of Fc receptors. Some explanations for the observed suppressive effect are discussed.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalActa Microbiologica Academiae Scientiarum Hungaricae
Volume25
Issue number3
Publication statusPublished - 1978

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Fc Receptors
Leukocytes
Lymphocytes
Antibodies
Antibody-Dependent Cell Cytotoxicity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Dialysable leukocyte extracts significantly inhibited the antibody-dependent cell-mediated cytotoxicity of normal human peripheral blood lymphocytes in both xenogeneic and allogeneic assays. The inhibitory effect was dose-dependent. Fractions of dialysable leukocyte extracts separated on Sephadex G-25 column differed in their capacity to suppress cytotoxicity. Dialysable leukocyte extracts did not block EA-rosetting but inhibited the resynthesis of Fc receptors. Some explanations for the observed suppressive effect are discussed.",
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AU - Láng, I.

AU - Fekete, B.

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