Effect of dantrolene sodium on the transmembrane potentials and contractility of guinea pig atrial myocardium

János Mészáros, V. Kecskeméti, József Szegi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Dantrolene sodium (3 × 10-4 M) exerted a biphasic effect on the mechanical and electrical activity of the isolated guinea pig left atrium. In the first phase, the drug increased the contractile force by about 200%, and prolonged the action potential duration. This transient positive inotropic effect was antagonized by D-600, a slow Ca2+ channel inhibitor. In the later phase, the drug gradually decreased the amplitude of contractions, shortened the action potential duration and induced contracture. Dantrolene sodium increased the rate of depolarization and overshoot of Ca2+ -mediated slow action potentials. The results suggest that dantrolene sodium increases the slow inward Ca2+ current, causing a positive inotropic effect in the atrial myocardium. The late negative inotropic effect of the drug could be due to a secondary inhibition of the slow inward Ca2+ current due to an increased intracellular free Ca2+ concentration as a consequence of other actions of the drug.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalEuropean Journal of Pharmacology
Volume74
Issue number2-3
DOIs
Publication statusPublished - Sep 11 1981

Fingerprint

Dantrolene
Membrane Potentials
Myocardium
Guinea Pigs
Action Potentials
Pharmaceutical Preparations
Gallopamil
Contracture
Heart Atria

Keywords

  • Action potential
  • Contractility
  • Dantrolene sodium
  • Guinea pig atrium
  • Slow responses

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effect of dantrolene sodium on the transmembrane potentials and contractility of guinea pig atrial myocardium. / Mészáros, János; Kecskeméti, V.; Szegi, József.

In: European Journal of Pharmacology, Vol. 74, No. 2-3, 11.09.1981, p. 181-188.

Research output: Contribution to journalArticle

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AB - Dantrolene sodium (3 × 10-4 M) exerted a biphasic effect on the mechanical and electrical activity of the isolated guinea pig left atrium. In the first phase, the drug increased the contractile force by about 200%, and prolonged the action potential duration. This transient positive inotropic effect was antagonized by D-600, a slow Ca2+ channel inhibitor. In the later phase, the drug gradually decreased the amplitude of contractions, shortened the action potential duration and induced contracture. Dantrolene sodium increased the rate of depolarization and overshoot of Ca2+ -mediated slow action potentials. The results suggest that dantrolene sodium increases the slow inward Ca2+ current, causing a positive inotropic effect in the atrial myocardium. The late negative inotropic effect of the drug could be due to a secondary inhibition of the slow inward Ca2+ current due to an increased intracellular free Ca2+ concentration as a consequence of other actions of the drug.

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