Oocyte quality has a strong influence on the outcome of in vitro fertilization treatments. In our retrospective study we analysed the data from 522 intracytoplasmic sperm injection treatments performed at the First Department of Obstetrics and Gynaecology, Semmelweis University, Faculty of Medicine, Budapest, between December, 2001 and February, 2005. We assessed the occurrence of various types of cytoplasmic vacuoles and their effect on the fertilization rate, cleavage rate and embryo quality. Almost 5% of the oocytes contained considerable amount of vacuoles or smooth endoplasmic reticulum (sER) clusters. These kind of dysmorphisms significantly reduced the fertilization and cleavage rate of the oocytes. Vacuoles did not affect the speed of embryonic development, however, sER clusters resulted in better embryo quality. Our data suggest that small vacuoles have no effect on the fertilization or cleavage rate of human embryos, while large vacuoles or sER clusters reduce the chance of fertilization. On the other hand, our observations regarding the embryo quality developing from oocytes with sER clusters contradiet the previously published data. Thus, a larger scale study is required in order to clarify the effect of sER clusters on oocyte and embryo viability.
|Translated title of the contribution||Effect of cytoplasmic vacuoles of human oocytes on further embryonal development and viability|
|Number of pages||9|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Nov 17 2006|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology