Effect of cycloheximide on viral precursor protein B in Sindbis virus infected BHK cells

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Abstract

The possible role of B protein, a postulated precursor of viral envelope proteins, was studied in Sindbis virus infected BHK cells. Although tryptic digestion of the B protein produces tryptic peptides of the viral envelope proteins it seems unlikely that B molecules accumulated in the cytoplasm of infected cells are subsequently cleaved into structural proteins. It is suggested that if B is really the precursor of E1 and PE2 viral envelope proteins, the cleavage takes place on the ribosomes during the synthesis of the second part of the B protein. Low concentrations of cycloheximide completely blocked the synthesis of B protein but did not inhibit the synthesis of viral structural proteins.

Original languageEnglish
Pages (from-to)368-371
Number of pages4
JournalMedical biology
Volume53
Issue number5
Publication statusPublished - Dec 1 1975

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ASJC Scopus subject areas

  • Medicine(all)

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