Tilorone hydrochloride (2,7 bis (2 diethylaminethoxy)fluren 9 one 2 HCl), administered to C57BL mice with the drinking water in a daily dose of about 50 mg/kg for a year, retarded significantly the appearance of tumors induced by a single s.c. dose of 120 μg methylcholanthrene dissolved in olive oil. Several signs of chronic toxicity were observed. No co oncogenic effect of tilorone was found.
|Number of pages||4|
|Publication status||Published - Dec 1 1974|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)