Effect of continual drinking of tilorone solution on methylcholanthrene oncogenesis in mice

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Tilorone hydrochloride (2,7 bis (2 diethylaminethoxy)fluren 9 one 2 HCl), administered to C57BL mice with the drinking water in a daily dose of about 50 mg/kg for a year, retarded significantly the appearance of tumors induced by a single s.c. dose of 120 μg methylcholanthrene dissolved in olive oil. Several signs of chronic toxicity were observed. No co oncogenic effect of tilorone was found.

Original languageEnglish
Pages (from-to)405-408
Number of pages4
Issue number2
Publication statusPublished - Dec 1 1974


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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