Effect of combined immunosuppressive-cytostatic treatment of antibody-dependent cellular cytotoxicity of patients with chronic glomerulonephritis

I. Lang, B. Fekete, B. Kenez, Z. K. Nagy, P. Gergely

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Abstract

Antibody-dependent cellular cytotoxicity by peripheral blood mononuclear cells was evaluated in 25 patients with chronic glomerulonephritis before and after combined vinblastine-cyclophosphamide-6-mercaptopurine-prednisolone therapy. Purified peripheral blood mononuclear cells of the patients mediated normal killed activity before the treatment and a strong suppression of their cytotoxic capacity was observed after the therapy. The possible significance of the inhibitory effect of immunosuppressive cytostatic treatment on human antibody-dependent cellular cytotoxicity is discussed.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalActa medica Academiae Scientiarum Hungaricae
Volume34
Issue number4
Publication statusPublished - Dec 1 1977

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ASJC Scopus subject areas

  • Medicine(all)

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