Effect of Co-Grinding on Crystallinity of Clopidogrel Bisulfate

Csaba Mártha, Orsolya Jójárt-Laczkovich, Piroska Szabó-Révész

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1 Citation (Scopus)

Abstract

A high energy input during pharmaceutical formulation is capable of decreasing the crystallinity of compounds in the product. The presence of the amorphous form can cause serious problems at any stage of the formulation. Crystallinity changes of a model powder mixture containing clopidogrel bisulfate (CLP) and a colloidal silicon dioxide as additive were investigated during a long-time co-grinding process. The crystallinity of CLP was reduced sigmoidally by co-grinding with longer co-grinding time. X-ray powder diffraction and differential scanning calorimetry examinations confirmed that the product had become totally amorphous after four hours of grinding. Thermogravimetric results proved that no major mass reduction happened and FT-IR changes referred to formulation of a secondary bond between the components.

Original languageEnglish
Pages (from-to)1393-1398
Number of pages6
JournalChemical Engineering and Technology
Volume37
Issue number8
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • Clopidogrel bisulfate
  • Co-grinding
  • Crystallinity
  • FT-IR

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

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