The effect of clofibrate has been studied in cholesterol fed rabbits. A very highly significant reduction of the serum lipid level could be established after 2 weeks of clofibrate treatment. In the aorta of cholesterol fed rabbits a slight increase of glycosaminoglycan concentration and intensive lipid deposition was found by histological, histochemical and electronmicroscopical methods. By thermal analysis the presence of aortic glycosaminoglycan serum beta lipoprotein complexes and the accumulation of 'abnormal' crosslinks within the fibrillar tissue proteins could be demonstrated in the intima of the animals. As a result of clofibrate treatment a significantly increased glycosaminoglycan content was found in the aorta of rabbits with experimental atherosclerosis. At the same time a decrease could be established in the amount of aortic glycosaminoglycan beta lipoprotein complexes. The anti atherogenic action of clofibrate influenced the pathologically changed protein structure as well: the cholesterol induced alterations proved to be partly reversible.
|Number of pages||13|
|Journal||Acta Medica Academiae Scientiarum Hungaricae|
|Publication status||Published - 1972|
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