EFFET DU CICLETANINE SUR LES ARYTHMIES ET L'ACCUMULATION INTRACELLULAIRE DU SODIUM DU COEUR ISOLE DE RAT AU COURS DE L'ISCHEMIE ET DE LA REPERFUSION

Translated title of the contribution: Effect of cicletanine on arrhythmia and intracellular sodium accumulation in the isolated rat heart during ischemia and perfusion

A. Tosaki, J. M. Guillon, M. Koltai, P. Braquet

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The antiarrhythmic effects of cicletanine (CIC), a new antihypertensive drugs, were studied on isolated hearts from SHR and WKY rats subjected to global normothermic ischaemia. The effects of CIC on variations in intracellular sodium concentration induced by ischaemia-reperfusion were measured. After a 14-day treatment with CIC in doses of 30 and 100 mg/kg/day, the results were as follows: in WKY rats the incidence of ventricular fibrillation (VF) was reduced from 91% in controls to 41% and 50% (p<0.05) and the incidence of ventricular tachycardia (VT) was reduced from 100% to 41% and 58% (p<0.05). In SHR rats the percentages of VF were 100% in controls and 17% (p<0.001) and 33% (p<0.01) respectively in treated animals. Similarly, the incidence of VT was reduced from 100% to 17% (p<0.001) and 25% (p<0.001) respectively. The effects of CIC were more pronounced on SHR rats than on WKY rats. CIC reduced the intracellular sodium accumulation induced by ischaemia and reperfusion. The antiarrhythmic activity of CIC seems to be correlated with its inhibitory activity on intracellular sodium accumulation.

Translated title of the contributionEffect of cicletanine on arrhythmia and intracellular sodium accumulation in the isolated rat heart during ischemia and perfusion
Original languageFrench
Title of host publicationArchives des Maladies du Coeur et des Vaisseaux
Pages155-161
Number of pages7
Volume82
EditionSPEC. ISS. 4
Publication statusPublished - Jan 1 1989

Keywords

  • arythmies
  • cicletanine
  • coeur isole
  • rats SHR et WKY
  • reperfusion
  • sodium intracellulaire

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Tosaki, A., Guillon, J. M., Koltai, M., & Braquet, P. (1989). EFFET DU CICLETANINE SUR LES ARYTHMIES ET L'ACCUMULATION INTRACELLULAIRE DU SODIUM DU COEUR ISOLE DE RAT AU COURS DE L'ISCHEMIE ET DE LA REPERFUSION. In Archives des Maladies du Coeur et des Vaisseaux (SPEC. ISS. 4 ed., Vol. 82, pp. 155-161)