Effect of cichorium intybus (L.) extract on the redox balance and metal ion content of fatty liver in hyperlipidemic rats

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, the physiological effect of the chicory extract was investigated in a short-term animal experiment in two different dietary animal groups. Male Wistar rats (150-200 g) were fed with a normal diet, and another group with a fat-rich diet (2% cholesterol, 0.5% cholic acid and 20% sunflower oil added to the basic diet) for 10 days. In each group, 10 animals were treated ad libitum with chicory extract (daily 2 g/bw/kg) parallel with the basic feedings. Histologic examinations were performed to evaluate the tissue alterations in the liver. Serum cholesterol and triacylglycerol concentrations changed parallel with the tissue degradation. The concentration of blood glucose was enhanced in both chicory-treated groups. Element concentrations of the chicory extract and liver homogenates were determined by ICP-OES. Upon treatment with chicory, the differences between the mean concentration values of Ca, Cu, Fe, K, Na, P and Zn in the liver homogenate of rats on the normal diet were significant. It was well-detected that the mean concentration values of Cr, Fe, K, Na, P and S in the liver homogenate of rats on the lipid-rich diet increased significantly. In the chicory supplemented lipid-rich dietary group, due to metal ion accumulation, some slight decrease could be detected in the diene conjugate content of the liver. Only moderate elevation was determined in the concentration of the free SH groups or in the value of reducing power of the liver tissue of rats in this short-term experiment. Consequently, more attention should be paid to the metal element and the oligosaccharide content of Cichorium intybus (L.) which may decrease the beneficial effect of the antioxidant compounds of the plant on the redox balance, and may contribute to the impairment of lipid and carbohydrate metabolism in the fatty liver.

Original languageEnglish
Pages (from-to)262-268
Number of pages7
JournalTrace Elements and Electrolytes
Volume21
Issue number4
Publication statusPublished - Nov 12 2004

    Fingerprint

Keywords

  • Cichorium intybus
  • Fatty liver
  • Metal elements
  • Redox balance

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Inorganic Chemistry

Cite this