Effect of cholecystokinin on self-stimulation behavior in rats

Mátyás Fekete, Axel Rentzsch, Helmut Schwarzberg, Gyula Telegdy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Experiments were performed to examine the effects of intracerebroventricularly administered cholecystokinin octapeptide sulfate ester (CCK-8-SE) and unsulfated cholecystokinin octapeptide (CCK-8-NS) on electrical self-stimulation behavior elicited from the medial forebrain bundle. CCK-8-SE and CCK-8-NS in 80 pmol doses reduced the response rate of self-stimulation behavior 22-30 min following injection, while 400 pmol doses of these peptides attenuated self-stimulation behavior between 13 and 36 min. It is suggested that CCK-8-SE and CCK-8-NS interact with central rather than peripheral nervous mechanisms.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalEuropean Journal of Pharmacology
Volume91
Issue number1
DOIs
Publication statusPublished - Jul 15 1983

Keywords

  • CCK octapeptides
  • Medial forebrain bundle
  • Self-stimulation behavior

ASJC Scopus subject areas

  • Pharmacology

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