Effect of cholecystokinin octapeptide sulphate ester on brain monoamines in the rat

M. Fekete, M. Varszegi, T. Kadar, B. Penke, K. Kovács, G. Telegdy

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Abstract

The effect of different doses of intracerebro-ventricularly administered cholecystokinin octapeptide sulphate ester (CCK-8-SE) was studied on dopamine (DA), norepinephrine (NE) and serotonin (5-HT) contents in the hypothalamus, mesencephalon, amygdala, septum and striatum, 10, 20 and 60 min following administration. The DA and NE content increased and the 5-HT content decreased in the hypothalamus and mesencephalon. A biphasic action was observed in the amygdala of DA, NE and 5-HT depending upon the time and doses used. Similar action was seen on DA and NE in the septum. In the striatum, the DA and 5-HT content decreased while the NE level first increased and then decreased. The data indicate that the CCK-8-SE is able to modify the activity of DA, NE and 5-HT in different brain regions in a time and dose-dependent manner, with a local specific action.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalActa physiologica Academiae Scientiarum Hungaricae
Volume57
Issue number1
Publication statusPublished - Dec 1 1981

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ASJC Scopus subject areas

  • Physiology

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