Effect of chlorpromazine and benzo [a] phenothiazines on heterotrophic auxin requiring and autotrophic auxin non-requiring tobacco tissue cultures

M. Szabo, J. Molnar, J. Csiszar, H. Motohashi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Chlorpromazine and four benzo[n]phenothiazines were tested on the growth and auxin level of auxin requiring heterotrophic and auxin non-requiring autotrophic tobacco tissue cultures originating from transgenic plants. The auxin content was followed by the expression of GUS reporter gene connected with auxin inducible mas promoter. The benzo[a]phenothiazines had a higher antiproliferative effect than chlorpromazine. The exogenous auxin non-requiring autotrophic callus was more sensitive than the auxin requiring heterotrophic callus (Based on the low GUS activity). The reduced growth of auxin autotrophic tissues may be due to the low endogenous auxin content.

Original languageEnglish
Pages (from-to)2113-2116
Number of pages4
JournalAnticancer research
Volume15
Issue number5 B
Publication statusPublished - Dec 1 1995

Keywords

  • Auxin (indoleacetic acid)
  • Benzo[a]]phenothiazines
  • Chlorpromazine
  • Tobacco tissue culture
  • β-glucuronidase (GUS) activity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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