The compound 1, 6-bis-(?-chloroethylamino)-1, 6-dideoxy-D-mannitol-dihydrochloride (Degranol; BCM) has been studied for its effects on the nucleic acid metabolism of Guerin carcinoma transplanted into rats. A single dose of the drug was found to decrease incorporation of 32p into the various nucleic acid fractions. At 72 hours after injection the decrease was most marked in DNA. It was less marked in nRNA and cRNA. At 96 hours, 32p incorporation into all the three nucleic acids studied was seen to have returned to the levels observed in the control animals. Variations of a similar trend were noted in the acidsoluble nucleotide fractions isolated simultaneously with the nucleic acids. The conclusion is drawn that the changes occurring in the nucleic metabolism of tumours represent a dynamic process, as do the morphological changes.
ASJC Scopus subject areas
- Cancer Research