Effect of chemotherapeutics on the nucleic acid metabolism of tumours incorporation of32p into nucleic acids following treatment with degranol

E. J. Hidvégi, F. Antoni, K. Lapis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The compound 1, 6-bis-(?-chloroethylamino)-1, 6-dideoxy-D-mannitol-dihydrochloride (Degranol; BCM) has been studied for its effects on the nucleic acid metabolism of Guerin carcinoma transplanted into rats. A single dose of the drug was found to decrease incorporation of 32p into the various nucleic acid fractions. At 72 hours after injection the decrease was most marked in DNA. It was less marked in nRNA and cRNA. At 96 hours, 32p incorporation into all the three nucleic acids studied was seen to have returned to the levels observed in the control animals. Variations of a similar trend were noted in the acidsoluble nucleotide fractions isolated simultaneously with the nucleic acids. The conclusion is drawn that the changes occurring in the nucleic metabolism of tumours represent a dynamic process, as do the morphological changes.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalBritish journal of cancer
Volume14
Issue number1
DOIs
Publication statusPublished - Mar 1960

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Effect of chemotherapeutics on the nucleic acid metabolism of tumours incorporation of<sup>32</sup>p into nucleic acids following treatment with degranol'. Together they form a unique fingerprint.

  • Cite this