The effect of agents influencing intracellular cyclic nucleotide levels and that of exogenous cAMP was studied on the cytotoxicity of normal human peripheral blood mononuclear cells on antibody coated human and chicken erythrocytes. Elevation of the cAMP level resulted in a marked decrease in cytotoxicity, while elevation of the cGMP level significantly enhanced cytotoxicity. These effects were basically similar in the allogeneic and the xenogeneic test systems, but more expressed in the allogeneic system.
|Number of pages||8|
|Journal||Acta medica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1978|
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