Effect of changes in cyclic nucleotide levels on human antibody-dependent cellular cytotoxicity

L. Kalmar, I. Lang, P. Gergely, B. Fekete, G. Petrányi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of agents influencing intracellular cyclic nucleotide levels and that of exogenous cAMP was studied on the cytotoxicity of normal human peripheral blood mononuclear cells on antibody coated human and chicken erythrocytes. Elevation of the cAMP level resulted in a marked decrease in cytotoxicity, while elevation of the cGMP level significantly enhanced cytotoxicity. These effects were basically similar in the allogeneic and the xenogeneic test systems, but more expressed in the allogeneic system.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalActa medica Academiae Scientiarum Hungaricae
Volume35
Issue number1
Publication statusPublished - Dec 1 1978

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Effect of changes in cyclic nucleotide levels on human antibody-dependent cellular cytotoxicity'. Together they form a unique fingerprint.

  • Cite this