Effect of CH-38083, a selective antagonist of alpha2-adrenoceptors, on renal sympathetic function

Margit Dóda, E. Vízi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of 7,8-(methylenedioxi)-14-α-hydroxyalloberbane HCl (CH-38083), a structurally new, selective and potent alpha2-adrenoceptor antagonist, and of idazoxan, were studied on both the spontaneous activity of the postganglionic sympathetic renal nerve and on the clonidine- or xylazineinduced inhibitory action in anaesthetized cats. The drug CH-38083 (30-200 μg/kg, i.v.) caused a sustained increase of the sympathetic activity and blood pressure. Larger doses of idazoxan (200-500 μg/kg, i.v.) were needed to induce similar effects. Both antagonists were effective in antagonizing the sympathoinhibitory effect of clonidine or xylazine. The excitatory response to selective alpha2-adrenoceptor antagonists suggests that the sympathetic output undergoes tonic inhibition due to a permanent alpha2-adrenoceptor stimulation.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalNeuropharmacology
Volume28
Issue number2
DOIs
Publication statusPublished - 1989

Fingerprint

Adrenergic Receptors
Idazoxan
Clonidine
Kidney
Xylazine
Cats
Blood Pressure
Pharmaceutical Preparations
7,8-(methylenedioxy)-14-hydroxyberbane

Keywords

  • alpha-adrenoceptor
  • CH-38083
  • renal sympathetic nerve activity
  • sympathoexcitation
  • sympathoinhibition

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Effect of CH-38083, a selective antagonist of alpha2-adrenoceptors, on renal sympathetic function. / Dóda, Margit; Vízi, E.

In: Neuropharmacology, Vol. 28, No. 2, 1989, p. 135-140.

Research output: Contribution to journalArticle

@article{80c9f9187fdd4222af85009b945f38fb,
title = "Effect of CH-38083, a selective antagonist of alpha2-adrenoceptors, on renal sympathetic function",
abstract = "The effects of 7,8-(methylenedioxi)-14-α-hydroxyalloberbane HCl (CH-38083), a structurally new, selective and potent alpha2-adrenoceptor antagonist, and of idazoxan, were studied on both the spontaneous activity of the postganglionic sympathetic renal nerve and on the clonidine- or xylazineinduced inhibitory action in anaesthetized cats. The drug CH-38083 (30-200 μg/kg, i.v.) caused a sustained increase of the sympathetic activity and blood pressure. Larger doses of idazoxan (200-500 μg/kg, i.v.) were needed to induce similar effects. Both antagonists were effective in antagonizing the sympathoinhibitory effect of clonidine or xylazine. The excitatory response to selective alpha2-adrenoceptor antagonists suggests that the sympathetic output undergoes tonic inhibition due to a permanent alpha2-adrenoceptor stimulation.",
keywords = "alpha-adrenoceptor, CH-38083, renal sympathetic nerve activity, sympathoexcitation, sympathoinhibition",
author = "Margit D{\'o}da and E. V{\'i}zi",
year = "1989",
doi = "10.1016/0028-3908(89)90049-X",
language = "English",
volume = "28",
pages = "135--140",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Effect of CH-38083, a selective antagonist of alpha2-adrenoceptors, on renal sympathetic function

AU - Dóda, Margit

AU - Vízi, E.

PY - 1989

Y1 - 1989

N2 - The effects of 7,8-(methylenedioxi)-14-α-hydroxyalloberbane HCl (CH-38083), a structurally new, selective and potent alpha2-adrenoceptor antagonist, and of idazoxan, were studied on both the spontaneous activity of the postganglionic sympathetic renal nerve and on the clonidine- or xylazineinduced inhibitory action in anaesthetized cats. The drug CH-38083 (30-200 μg/kg, i.v.) caused a sustained increase of the sympathetic activity and blood pressure. Larger doses of idazoxan (200-500 μg/kg, i.v.) were needed to induce similar effects. Both antagonists were effective in antagonizing the sympathoinhibitory effect of clonidine or xylazine. The excitatory response to selective alpha2-adrenoceptor antagonists suggests that the sympathetic output undergoes tonic inhibition due to a permanent alpha2-adrenoceptor stimulation.

AB - The effects of 7,8-(methylenedioxi)-14-α-hydroxyalloberbane HCl (CH-38083), a structurally new, selective and potent alpha2-adrenoceptor antagonist, and of idazoxan, were studied on both the spontaneous activity of the postganglionic sympathetic renal nerve and on the clonidine- or xylazineinduced inhibitory action in anaesthetized cats. The drug CH-38083 (30-200 μg/kg, i.v.) caused a sustained increase of the sympathetic activity and blood pressure. Larger doses of idazoxan (200-500 μg/kg, i.v.) were needed to induce similar effects. Both antagonists were effective in antagonizing the sympathoinhibitory effect of clonidine or xylazine. The excitatory response to selective alpha2-adrenoceptor antagonists suggests that the sympathetic output undergoes tonic inhibition due to a permanent alpha2-adrenoceptor stimulation.

KW - alpha-adrenoceptor

KW - CH-38083

KW - renal sympathetic nerve activity

KW - sympathoexcitation

KW - sympathoinhibition

UR - http://www.scopus.com/inward/record.url?scp=0024562266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024562266&partnerID=8YFLogxK

U2 - 10.1016/0028-3908(89)90049-X

DO - 10.1016/0028-3908(89)90049-X

M3 - Article

C2 - 2566132

AN - SCOPUS:0024562266

VL - 28

SP - 135

EP - 140

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 2

ER -