Effect of CH-38083, a selective antagonist of alpha2-adrenoceptors, on renal sympathetic function

Margit Dóda, E. S. Vizi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of 7,8-(methylenedioxi)-14-α-hydroxyalloberbane HCl (CH-38083), a structurally new, selective and potent alpha2-adrenoceptor antagonist, and of idazoxan, were studied on both the spontaneous activity of the postganglionic sympathetic renal nerve and on the clonidine- or xylazineinduced inhibitory action in anaesthetized cats. The drug CH-38083 (30-200 μg/kg, i.v.) caused a sustained increase of the sympathetic activity and blood pressure. Larger doses of idazoxan (200-500 μg/kg, i.v.) were needed to induce similar effects. Both antagonists were effective in antagonizing the sympathoinhibitory effect of clonidine or xylazine. The excitatory response to selective alpha2-adrenoceptor antagonists suggests that the sympathetic output undergoes tonic inhibition due to a permanent alpha2-adrenoceptor stimulation.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalNeuropharmacology
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 1989

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Keywords

  • CH-38083
  • alpha-adrenoceptor
  • renal sympathetic nerve activity
  • sympathoexcitation
  • sympathoinhibition

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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