Effect of central early postnatal 6 hydroxydopamine administration on brain catecholamines and pituitary adrenal function in adulthood

J. Kaplanski, C. Nyakas, A. M.L. Van Delft, P. G. Smelik

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Central administration of 6 hydroxydopamine (60HDA) to newborn rats induced a dose dependent and long lasting decrease in noradrenaline (NA) and dopamine (DA) content in adult male and female rat brain. After postnatal administration of 100 μg 60HDA, a decrease of about 50% of NA and DA content of the whole brain was found in 9 to 10 wk old rats; 200 μg 60HDA induced a reduction of 80% of NA and DA content. The latter treatment was followed by a severe growth retardation, a marked myosis, a decrease in general activity, and disappearance of clonic convulsions after decapitation. At the same time, however, in both groups of animals no change in basal pituitary adrenal activity was found, as evaluated by measurement of corticosterone in plasma, in vitro adrenal corticoid production, and adrenal weight. Apparently even severe inhibition of the development of central DA and NA systems by 60HDA administration to the newborn rat did not induce any change in basal pituitary adrenal functioning.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalNeuroendocrinology
Volume13
Issue number1-2
DOIs
Publication statusPublished - Jan 1 1974

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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