Effect of carboxymethyl-β-cyclodextrin on the hydrophobicity parameters of steroidal drugs

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The interaction between 17 steroidal drugs and carboxymethyl-β-cyclodextrin (CMβCD) was determined by charge-transfer chromatography and the relative strength of interaction was calculated. CMβCD interacted with the majority of steroidal drugs decreasing the hydrophobicity of the guest molecules. The relative strength of interaction considerably depended on the structure of the drug molecule. The hydrophobicity parameters of the drugs significantly influenced the strength of interaction indicating the involvement of hydrophobic forces in the binding of drugs to CMβCD. The marked influence of CMβCD on the hydrophobicity of drugs suggests that this interaction may have a considerable impact on the biological properties (adsorption, uptake, half-life etc,) of drug - CMβCD complexes resulting in modified efficacy.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalCarbohydrate Polymers
Volume38
Issue number2
Publication statusPublished - Feb 1999

Fingerprint

cyclodextrins
Cyclodextrins
Hydrophobicity
hydrophobicity
Hydrophobic and Hydrophilic Interactions
drugs
Pharmaceutical Preparations
Molecules
drug interactions
Chromatography
Charge transfer
Drug Interactions
Adsorption
half life
Half-Life
chromatography
adsorption

Keywords

  • Carboxymethyl-β-cyclodextrin
  • Hydrophobicity
  • Steroidal drugs

ASJC Scopus subject areas

  • Food Science
  • Biochemistry

Cite this

Effect of carboxymethyl-β-cyclodextrin on the hydrophobicity parameters of steroidal drugs. / Cserháti, T.; Forgács, E.

In: Carbohydrate Polymers, Vol. 38, No. 2, 02.1999, p. 171-177.

Research output: Contribution to journalArticle

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