Effect of capsaicin and resiniferatoxin on gastrointestinal blood flow in rats

Omar M E Abdel Salam, J. Szolcsányi, R. Pórszász, G. Mózsik

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effect of capsaicin and resiniferatoxin on gastrointestinal blood flow was studied in anaesthetized rats by laser Doppler flowmetry. Resiniferatoxin injected into the jugular vein (0.08-1.6 nmol/kg) produced a marked and dose-dependent increase in gastric blood flow, while the effect of capsaicin (0.33-19.6 nmol/kg) was transient, variable and accompanied by profound systemic blood pressure changes. After acute bilateral cervical vagotomy combined with sympathetic neurone blockade (guanethidine 16 μmol/kg) or α-adrenoceptor blockade (phentolamine 1.6 μmol/kg), the vasodilator response to injected resiniferatoxin was more pronounced, indicating that the resiniferatoxin-induced gastric vasodilatation is not due to reflexes via parasympathetic or sympathetic efferent fibres. Resiniferatoxin given i.v. (0.08-0.64 nmol/kg) evoked a similar increase in the blood flow of the jejunum. Capsaicin (0.33-33 μM) or resiniferatoxin (0.16-1.6 μM) applied topically to the serosal surface of the stomach or jejunum produced a pronounced and long-lasting increase in blood flow after vagotomy and guanethidine treatment. The blood flow and blood pressure responses to capsaicin and resiniferatoxin were absent in rats desensitized with systemic capsaicin pretreatment. These laser Doppler data provide the first evidence for the effect of resiniferatoxin on gastrointestinal microcirculation and indicate the advantages of this agent and technique to study the sensory-efferent function of capsaicin-sensitive fibres.

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalEuropean Journal of Pharmacology
Volume305
Issue number1-3
DOIs
Publication statusPublished - Jun 3 1996

Fingerprint

Capsaicin
Guanethidine
Stomach
Vagotomy
Jejunum
Blood Pressure
Adrenergic Fibers
Laser-Doppler Flowmetry
resiniferatoxin
Phentolamine
Jugular Veins
Microcirculation
Vasodilator Agents
Vasodilation
Adrenergic Receptors
Reflex
Lasers
Neurons

Keywords

  • capsaicin
  • gastrointestinal microcirculation
  • laser Doppler
  • resiniferatoxin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effect of capsaicin and resiniferatoxin on gastrointestinal blood flow in rats. / Abdel Salam, Omar M E; Szolcsányi, J.; Pórszász, R.; Mózsik, G.

In: European Journal of Pharmacology, Vol. 305, No. 1-3, 03.06.1996, p. 127-136.

Research output: Contribution to journalArticle

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