A kalciumcsatorna-blokkolok inyre kifejtett hatasanak vizsgalata belgyogyaszati betegeken

Translated title of the contribution: Effect of calcium channel blocking drugs on the periodontal status of hospitalized patients

T. Keglevich, E. Zsidro, E. Benedek, I. Barna, Z. Szegedi, E. R. Schwab, I. Gera

Research output: Contribution to journalArticle

Abstract

INTRODUCTION - Ca2+-channel blockers play crucial role in the chronic treatment of hypertension and cardiac arrhythmia. One of the side effects of the chronic nifedipine treatment is gingival enlargement. The pathomechanism of this side effect is not fully understood. The main objective of the present study was to evaluate the potential role of different factors in the development and severity of gingival hyperplasia. PATIENTS AND METHODS - The incidence and severity of gingival enlargement were examined around the six surfaces of all fully erupted teeth in 243 hospitalized patients with the modified Angelopoulus-Goaz Gingival Hyperplasia Index. 172 patients in the study group were on Ca2+-channel blockers for at least three months prior to the examination while 71 inpatients served as controls. RESULTS - Gingival hyperplasia occurred in 87% of he test group and in 53% of the control group. Severe gingival enlargement occurred in 35% in the test group and only in 2% of the control group. The age and gender of the patient, the daily dose of the medication, the duration of the administration of the drug showed no correlation with the extent and severity of gingival hyperplasia. Only oral hygiene showed statistically significant correlation with the severity of gingival enlargement. CONCLUSION - The only clinical parameter influencing the extent and severity of gingival enlargement associated with Ca2+-channel blocker drugs was the quality of oral hygiene.

Original languageHungarian
Pages (from-to)680-684
Number of pages5
JournalLege Artis Medicinae
Volume10
Issue number9
Publication statusPublished - 2000

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Gingival Hyperplasia
Calcium Channel Blockers
Oral Hygiene
Periodontal Index
Control Groups
Nifedipine
Pharmaceutical Preparations
Cardiac Arrhythmias
Inpatients
Tooth
Hypertension
Incidence
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Keglevich, T., Zsidro, E., Benedek, E., Barna, I., Szegedi, Z., Schwab, E. R., & Gera, I. (2000). A kalciumcsatorna-blokkolok inyre kifejtett hatasanak vizsgalata belgyogyaszati betegeken. Lege Artis Medicinae, 10(9), 680-684.

A kalciumcsatorna-blokkolok inyre kifejtett hatasanak vizsgalata belgyogyaszati betegeken. / Keglevich, T.; Zsidro, E.; Benedek, E.; Barna, I.; Szegedi, Z.; Schwab, E. R.; Gera, I.

In: Lege Artis Medicinae, Vol. 10, No. 9, 2000, p. 680-684.

Research output: Contribution to journalArticle

Keglevich, T, Zsidro, E, Benedek, E, Barna, I, Szegedi, Z, Schwab, ER & Gera, I 2000, 'A kalciumcsatorna-blokkolok inyre kifejtett hatasanak vizsgalata belgyogyaszati betegeken', Lege Artis Medicinae, vol. 10, no. 9, pp. 680-684.
Keglevich T, Zsidro E, Benedek E, Barna I, Szegedi Z, Schwab ER et al. A kalciumcsatorna-blokkolok inyre kifejtett hatasanak vizsgalata belgyogyaszati betegeken. Lege Artis Medicinae. 2000;10(9):680-684.
Keglevich, T. ; Zsidro, E. ; Benedek, E. ; Barna, I. ; Szegedi, Z. ; Schwab, E. R. ; Gera, I. / A kalciumcsatorna-blokkolok inyre kifejtett hatasanak vizsgalata belgyogyaszati betegeken. In: Lege Artis Medicinae. 2000 ; Vol. 10, No. 9. pp. 680-684.
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AU - Gera, I.

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AB - INTRODUCTION - Ca2+-channel blockers play crucial role in the chronic treatment of hypertension and cardiac arrhythmia. One of the side effects of the chronic nifedipine treatment is gingival enlargement. The pathomechanism of this side effect is not fully understood. The main objective of the present study was to evaluate the potential role of different factors in the development and severity of gingival hyperplasia. PATIENTS AND METHODS - The incidence and severity of gingival enlargement were examined around the six surfaces of all fully erupted teeth in 243 hospitalized patients with the modified Angelopoulus-Goaz Gingival Hyperplasia Index. 172 patients in the study group were on Ca2+-channel blockers for at least three months prior to the examination while 71 inpatients served as controls. RESULTS - Gingival hyperplasia occurred in 87% of he test group and in 53% of the control group. Severe gingival enlargement occurred in 35% in the test group and only in 2% of the control group. The age and gender of the patient, the daily dose of the medication, the duration of the administration of the drug showed no correlation with the extent and severity of gingival hyperplasia. Only oral hygiene showed statistically significant correlation with the severity of gingival enlargement. CONCLUSION - The only clinical parameter influencing the extent and severity of gingival enlargement associated with Ca2+-channel blocker drugs was the quality of oral hygiene.

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