Effect of caidiopulmonary bypass on cytokine network and myocardial cytokine production

B. Gasz, L. Lénárd, B. Rácz, L. Benko, B. Borsiczky, B. Cserepes, J. Gál, G. Jancso, J. Lantos, S. Ghosh, S. Szabados, L. Papp, N. Alotti, E. Rőth

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: In addition to the well-investigated proinflammatory cytokine expression, there is an ever increasing interest in the field of anti-inflammatory response to cardiopulmonary bypass (CPB). Evidence suggests that myocardium serves as an important source of cytokines during reperfusion and application of CPB. The effect of coronary artery bypass graft (CABG) without CPB on myocardial cytokine production has not as yet been investigated. Hypothesis: Cardiopulmonary bypass can cause long-term disturbance in pro- and anti-inflammatory cytokine balance, which may impede a patient's recovery following surgery. Therefore, the effect of CPB on the balance of the pro-/anti-inflammatory cytokines network and myocardial cytokine outflow was assessed throughout a longer period after surgery. Methods: Twenty patients were scheduled for CABG with CPB and 10 had off-pump surgery. Blood samples were taken before, during, and over the first week following surgery. Coronary sinus blood samples were collected during surgery. The ratio of pro- and anti-inflammatory cytokines was calculated and the cytokine concentration of peripheral and coronary sinus blood were compared in both groups. Results: Pro-/anti-inflammatory cytokine ratio decreased early after CPB followed by a delayed and marked increase. A more balanced ratio was present following off-pump surgery. Coronary sinus levels of certain cy tokines exceeded the concentration of systemic blood in the course of CPB but not during off-pump operation. Conclusion: Patients show pro-inflammatory predominant cytokine balance at a later stage after CPB in contrast to those without CPB. The heart produces a remarkable amount of cytokines only in the course of surgery with CPB.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalClinical Cardiology
Volume29
Issue number7
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Cardiopulmonary Bypass
Cytokines
Anti-Inflammatory Agents
Coronary Sinus
Coronary Artery Bypass
Transplants
Reperfusion
Myocardium

Keywords

  • Cardiopulmonary bypass
  • Coronary artery bypass graft
  • Cytokines
  • Inflammatory response
  • Myocardial injury

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of caidiopulmonary bypass on cytokine network and myocardial cytokine production. / Gasz, B.; Lénárd, L.; Rácz, B.; Benko, L.; Borsiczky, B.; Cserepes, B.; Gál, J.; Jancso, G.; Lantos, J.; Ghosh, S.; Szabados, S.; Papp, L.; Alotti, N.; Rőth, E.

In: Clinical Cardiology, Vol. 29, No. 7, 07.2006, p. 311-315.

Research output: Contribution to journalArticle

@article{73393b14bc8947c99ab808b80d398cc5,
title = "Effect of caidiopulmonary bypass on cytokine network and myocardial cytokine production",
abstract = "Background: In addition to the well-investigated proinflammatory cytokine expression, there is an ever increasing interest in the field of anti-inflammatory response to cardiopulmonary bypass (CPB). Evidence suggests that myocardium serves as an important source of cytokines during reperfusion and application of CPB. The effect of coronary artery bypass graft (CABG) without CPB on myocardial cytokine production has not as yet been investigated. Hypothesis: Cardiopulmonary bypass can cause long-term disturbance in pro- and anti-inflammatory cytokine balance, which may impede a patient's recovery following surgery. Therefore, the effect of CPB on the balance of the pro-/anti-inflammatory cytokines network and myocardial cytokine outflow was assessed throughout a longer period after surgery. Methods: Twenty patients were scheduled for CABG with CPB and 10 had off-pump surgery. Blood samples were taken before, during, and over the first week following surgery. Coronary sinus blood samples were collected during surgery. The ratio of pro- and anti-inflammatory cytokines was calculated and the cytokine concentration of peripheral and coronary sinus blood were compared in both groups. Results: Pro-/anti-inflammatory cytokine ratio decreased early after CPB followed by a delayed and marked increase. A more balanced ratio was present following off-pump surgery. Coronary sinus levels of certain cy tokines exceeded the concentration of systemic blood in the course of CPB but not during off-pump operation. Conclusion: Patients show pro-inflammatory predominant cytokine balance at a later stage after CPB in contrast to those without CPB. The heart produces a remarkable amount of cytokines only in the course of surgery with CPB.",
keywords = "Cardiopulmonary bypass, Coronary artery bypass graft, Cytokines, Inflammatory response, Myocardial injury",
author = "B. Gasz and L. L{\'e}n{\'a}rd and B. R{\'a}cz and L. Benko and B. Borsiczky and B. Cserepes and J. G{\'a}l and G. Jancso and J. Lantos and S. Ghosh and S. Szabados and L. Papp and N. Alotti and E. Rőth",
year = "2006",
month = "7",
doi = "10.1002/clc.4960290708",
language = "English",
volume = "29",
pages = "311--315",
journal = "Clinical Cardiology",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - Effect of caidiopulmonary bypass on cytokine network and myocardial cytokine production

AU - Gasz, B.

AU - Lénárd, L.

AU - Rácz, B.

AU - Benko, L.

AU - Borsiczky, B.

AU - Cserepes, B.

AU - Gál, J.

AU - Jancso, G.

AU - Lantos, J.

AU - Ghosh, S.

AU - Szabados, S.

AU - Papp, L.

AU - Alotti, N.

AU - Rőth, E.

PY - 2006/7

Y1 - 2006/7

N2 - Background: In addition to the well-investigated proinflammatory cytokine expression, there is an ever increasing interest in the field of anti-inflammatory response to cardiopulmonary bypass (CPB). Evidence suggests that myocardium serves as an important source of cytokines during reperfusion and application of CPB. The effect of coronary artery bypass graft (CABG) without CPB on myocardial cytokine production has not as yet been investigated. Hypothesis: Cardiopulmonary bypass can cause long-term disturbance in pro- and anti-inflammatory cytokine balance, which may impede a patient's recovery following surgery. Therefore, the effect of CPB on the balance of the pro-/anti-inflammatory cytokines network and myocardial cytokine outflow was assessed throughout a longer period after surgery. Methods: Twenty patients were scheduled for CABG with CPB and 10 had off-pump surgery. Blood samples were taken before, during, and over the first week following surgery. Coronary sinus blood samples were collected during surgery. The ratio of pro- and anti-inflammatory cytokines was calculated and the cytokine concentration of peripheral and coronary sinus blood were compared in both groups. Results: Pro-/anti-inflammatory cytokine ratio decreased early after CPB followed by a delayed and marked increase. A more balanced ratio was present following off-pump surgery. Coronary sinus levels of certain cy tokines exceeded the concentration of systemic blood in the course of CPB but not during off-pump operation. Conclusion: Patients show pro-inflammatory predominant cytokine balance at a later stage after CPB in contrast to those without CPB. The heart produces a remarkable amount of cytokines only in the course of surgery with CPB.

AB - Background: In addition to the well-investigated proinflammatory cytokine expression, there is an ever increasing interest in the field of anti-inflammatory response to cardiopulmonary bypass (CPB). Evidence suggests that myocardium serves as an important source of cytokines during reperfusion and application of CPB. The effect of coronary artery bypass graft (CABG) without CPB on myocardial cytokine production has not as yet been investigated. Hypothesis: Cardiopulmonary bypass can cause long-term disturbance in pro- and anti-inflammatory cytokine balance, which may impede a patient's recovery following surgery. Therefore, the effect of CPB on the balance of the pro-/anti-inflammatory cytokines network and myocardial cytokine outflow was assessed throughout a longer period after surgery. Methods: Twenty patients were scheduled for CABG with CPB and 10 had off-pump surgery. Blood samples were taken before, during, and over the first week following surgery. Coronary sinus blood samples were collected during surgery. The ratio of pro- and anti-inflammatory cytokines was calculated and the cytokine concentration of peripheral and coronary sinus blood were compared in both groups. Results: Pro-/anti-inflammatory cytokine ratio decreased early after CPB followed by a delayed and marked increase. A more balanced ratio was present following off-pump surgery. Coronary sinus levels of certain cy tokines exceeded the concentration of systemic blood in the course of CPB but not during off-pump operation. Conclusion: Patients show pro-inflammatory predominant cytokine balance at a later stage after CPB in contrast to those without CPB. The heart produces a remarkable amount of cytokines only in the course of surgery with CPB.

KW - Cardiopulmonary bypass

KW - Coronary artery bypass graft

KW - Cytokines

KW - Inflammatory response

KW - Myocardial injury

UR - http://www.scopus.com/inward/record.url?scp=33745913333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745913333&partnerID=8YFLogxK

U2 - 10.1002/clc.4960290708

DO - 10.1002/clc.4960290708

M3 - Article

C2 - 16881540

AN - SCOPUS:33745913333

VL - 29

SP - 311

EP - 315

JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 7

ER -